Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

Table 1

Body and adrenal weight in DEX-treated mice and rats.

	Mice			Rats
	Body weight (g)		Adrenal weight (mg/100 g b.w.)	Body weight (g)		Adrenal weight (mg/100 g b.w.)
	Before	After	After	Before	After	After
CTL	38.7 ± 0.6	40.2 ± 0.6	18.21 ± 1.74	340.1 ± 6.5	351.2 ± 11.5	17.5 ± 1.12
DEX	39.4 ± 0.8	37.9 ± 0.7^†	12.68 ± 0.72*	346.7 ± 11.2	309.6 ± 10.8^†	11.38 ± 0.78*

Significantly different using unpaired -test versus DEX before treatment; significantly different using unpaired -test versus CTL after treatment ; = 6–8; values are mean ± s.e.m.