Correlations of Vascular Architecture and Angiogenesis with Pituitary Adenoma Histotype

Table 3

Morphometric analysis of vascular architecture between adenoma function.

	NF		PRL		GH		ACTH		TSH
	mean	SD	mean	SD	mean	SD	mean	SD	mean
All cases	n 24		n 13		n 10		n 3		n 1
Density/1.0 mm^2	56.6	33.5	46.8	25.7	52.7	24.6	24.2	13.3	83
Area %	6.24	4.24	7.59	4.55	5.66	5.90	2.72	0.76	6.27
Diameter m	12.1	2.4	14.1^*	3.0	10.8	2.6	13.5	4.7	9.58	to GH
Perimeter m	55.7	14.2	67.5	15.7	53.0	17.3	66.5	20.7	47.5
Roundness	0.57	0.06	0.529	0.053	0.54	0.072	0.481	0.057	0.471
VEGF-positive case	n 11		n 7		n 8		n 0		n 1
Density/1.0 mm^2	63.8	36.7	50.3	25.9	51.0	27.1	nd		83
Area %	7.13	5.37	9.19	5.18	5.59	6.56	nd		6.27
Diameter m	11.9	2.7	14.9^*	3.0	10.8	2.8	nd		9.58	to GH
Perimeter m	56.4	17.4	72.0	15.7	52.1	18.9	nd		47.5
Roundness	0.564	0.032	0.515	0.0543	0.557	0.0699	nd		0.471
Macroadenoma case	n 24		n 10		n 8		n 2		n 0
Density/1.0 mm^2	56.6	33.3	44.3	24.1	49.2	24.9	16.7	23.3	nd
Area %	6.2	4.2	8.4	4.6	5.7	6.60	3.1	0.32	nd
Diameter m	12.1	2.4	15.2^**	2.4	11.1	2.8	16.2	0.2	nd	to NF, GH
Perimeter m	55.7	14.2	72.7^*	12.9	53.3	19.4	78.3	4.7	nd	to NF, GH
Roundness	0.571	0.064	0.527	0.060	0.558	0.069	0.503	0.060	nd