Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma

Table 3

Association between γH2AX expression and clinicopathological features.

	Number	γH2AX-low		γH2AX-high		value
			%		%
Total number
Distant metastasis						0.17
−	134	36	26.9%	98	73.1%
+	19	8	42.1%	11	57.9%
T classification						<0.001
1	11	0	0.0%	11	100.0%
2	7	1	14.3%	6	85.7%
3	84	13	15.5%	71	84.5%
4	51	30	58.8%	21	41.2%
Lymph node metastasis						0.1
−	46	9	19.6%	37	80.4%
+	107	35	32.7%	72	67.3%
TNM stage (2002 AJCC)						<0.001
I	49	5	10.2%	44	89.8%
II	7	3	42.9%	4	57.1%
III	42	5	11.9%	37	88.1%
IV	55	31	56.4%	24	43.6%
Differentiation						<0.001
Well differentiated	110	11	10.0%	99	90.0%
Poorly differentiated	22	15	68.2%	7	31.8%
Anaplastic	21	18	85.7%	3	14.3%
TPOAb						0.376
N	120	30	25.0%	90	75.0%
H	27	9	33.3%	18	66.7%
TgAb
N	119	30	25.2%	89	74.8%	0.455
H	28	9	32.1%	19	67.9%
T3
L	6	1	16.7%	5	83.3%	0.421
N	141	40	28.4%	101	71.6%
H	2	0	0.0%	2	100.0%
FT3
L	10	5	50.0%	5	50.0%	0.043
N	130	31	23.8%	99	76.2%
H	9	5	55.6%	4	44.4%
T4						0.308
L	3	1	33.3%	2	66.7%
N	133	34	25.6%	99	74.4%
H	13	6	46.2%	7	53.8%
FT4						0.009
L	7	4	57.1%	3	42.9%
N	135	32	23.7%	103	76.3%
H	7	5	71.4%	2	28.6%
TSH						<0.001
L	7	6	85.7%	1	14.3%
N	133	27	20.3%	106	79.7%
H	9	8	88.9%	1	11.1%
Tg						0.082
L	14	5	35.7%	9	64.3%
N	97	20	20.6%	77	79.4%
H	36	14	38.9%	22	61.1%