Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma

Table 4

Association between ATM expression and clinicopathological features.

	Number	γH2AX-low		γH2AX-high		value
			%		%
Total number
Distant metastasis						0.183
−	134	85	63.4%	49	36.6%
+	19	15	78.9%	4	21.1%
T classification
1	11	9	81.8%	2	18.2%	0.287
2	7	6	85.7%	1	14.3%
3	84	51	60.7%	33	39.3%
4	51	34	66.7%	17	33.3%
Lymph node metastasis						0.132
−	46	26	56.5%	20	43.5%
+	107	74	69.2%	33	30.8%
TNM stage (2002 AJCC)						0.602
I	49	33	67.3%	16	32.7%
II	7	6	85.7%	1	14.3%
III	42	26	61.9%	16	38.1%
IV	55	35	63.6%	20	36.4%
Differentiation						0.05
Well differentiated	110	70	63.6%	40	36.4%
Poorly differentiated	22	19	86.4%	3	13.6%
Anaplastic	21	11	52.4%	10	47.6%
TPOAb						0.541
N	120	77	64.2%	43	35.8%
H	27	19	70.4%	8	29.6%
TgAb						0.231
N	119	75	63.0%	44	37.0%
H	28	21	75.0%	7	25.0%
T3						0.548
L	6	5	83.3%	1	16.7%
N	141	91	64.5%	50	35.5%
H	2	1	50.0%	1	50.0%
FT3						0.009
L	10	8	80.0%	2	20.0%
N	130	80	61.5%	50	38.5%
H	9	9	100.0%	0	0.0%
T4						0.037
L	3	3	100.0%	0	0.0%
N	133	89	66.9%	44	33.1%
H	13	5	38.5%	8	61.5%
FT4						0.448
L	7	3	42.9%	4	57.1%
N	135	89	65.9%	46	34.1%
H	4	5	125.0%	2	50.0%
TSH						0.448
L	7	6	85.7%	1	14.3%
N	133	85	63.9%	48	36.1%
H	9	6	66.7%	3	33.3%
Tg						0.505
L	14	11	78.6%	3	21.4%
N	97	61	62.9%	36	37.1%
H	36	24	66.7%	12	33.3%