Research Article
Profiling of Somatic Mutations in Phaeochromocytoma and Paraganglioma by Targeted Next Generation Sequencing Analysis
Table 3
Meta-analysis of
mutations in phaeochromocytoma, paraganglioma, and HNPGL.
| Study | Frequency of mutations in phaeochromocytoma | Frequency of mutations in paraganglioma | Frequency of mutations in HNPGL | All | Positive samples | Sporadic | Positive samples | Inherited | All | Positive samples | Sporadic | Positive samples | Inherited | All | Positive samples | Sporadic | Positive samples | Inherited |
| Current study | 60 | 6 | 44 | 0 | 16 | 5 | 0 | 5 | 0 | 0 | 20 | 0 | 15 | 0 | 5 | Crona et al. [19] | 72 | 3 | 50 | 0 | 22 | 9 | 1 | 6 | 0 | 3 | 1 | 0 | 1 | 0 | 0 | Oudijk et al. [20] | 216 | 14 | 140 | 0 | 76 | 55 | 0 | 24 | 0 | 31 | 0 | 0 | 0 | 0 | 0 |
| Total | 348 | 23 | 234 | 0 | 114 | 69 | 1 | 35 | 0 | 34 | 21 | 0 | 16 | 0 | 5 |
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