17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats

Figure 6

Representative micrographs of electron microscopy of renal capillary loops (20000x). C rats, no abnormalities are found. The images from MS and MSovx rats show abnormalities in basal membrane with endothelial edema and filiform podocyte in some zones. The images from the MSovx + E₂ rats show abnormalities in basal membrane with remodeling and thickness variability; the podocyte processes have almost disappeared and the fenestrated endothelium is lost or obliterated in many areas. C: control, MS: metabolic syndrome, MSovx: metabolic syndrome ovariectomized, MSovx + E₂: metabolic syndrome ovariectomized plus estradiol, BM: basal membrane, E: endothelium, ED: edema, L: lumen, and P: podocyte.