17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats

Table 1

General characteristics in experimental groups.

Variables	C	MS	MSovx	MSovx + E2
SBP (mmHg)	117.1 ± 1.0			134.4 ± 0.8
Body weight (g)	239.0 ± 6.0			295.9 ± 4.4
Intra-abdominal fat (g)	4.8 ± 0.5			6.0 ± 0.1
Cholesterol (mg/dL)	37.5 ± 4.1	38.8 ± 2.1	39.4 ± 1.5	32.2 ± 5.8
Triglycerides (mg/dL)	105.9 ± 1.1			124.8 ± 4.2
Glucose (mmol/L)	4.4 ± 0.4	5.4 ± 0.3	6.6 ± 0.3	4.3 ± 0.3
Insulin (μUI/L)	0.4 ± 0.1			4.9 ± 0.3
HOMA index	0.1 ± 0.0			0.8 ± 0.1
Estradiol (pg/mL)	24.8 ± 3.2	29.1 ± 5.8		26.8 ± 3.6
Kidney weight (g)	1.0 ± 0.0	0.8 ± 0.0	0.8 ± 0.0	1.0 ± 0.1
Albuminuria (mg/24 hours)	3.4 ± 1.8	1.1 ± 2.4		3.3 ± 4.8
Creatinine clearance (mL/min)	0.04 ± 0.003	0.03 ± 0.003		0.03 ± 0.008

Data are means ± SE; for each group. Statistically significant at C versus MS ; ; and MS and MSovx + E₂ versus MSovx ; ; . C: control; MS: metabolic syndrome; MSovx: metabolic syndrome ovariectomized; MSovx + E₂: metabolic syndrome ovariectomized plus estradiol.