17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats
Table 1
General characteristics in experimental groups.
Variables
C
MS
MSovx
MSovx + E2
SBP (mmHg)
117.1 ± 1.0
134.4 ± 0.8
Body weight (g)
239.0 ± 6.0
295.9 ± 4.4
Intra-abdominal fat (g)
4.8 ± 0.5
6.0 ± 0.1
Cholesterol (mg/dL)
37.5 ± 4.1
38.8 ± 2.1
39.4 ± 1.5
32.2 ± 5.8
Triglycerides (mg/dL)
105.9 ± 1.1
124.8 ± 4.2
Glucose (mmol/L)
4.4 ± 0.4
5.4 ± 0.3
6.6 ± 0.3
4.3 ± 0.3
Insulin (μUI/L)
0.4 ± 0.1
4.9 ± 0.3
HOMA index
0.1 ± 0.0
0.8 ± 0.1
Estradiol (pg/mL)
24.8 ± 3.2
29.1 ± 5.8
26.8 ± 3.6
Kidney weight (g)
1.0 ± 0.0
0.8 ± 0.0
0.8 ± 0.0
1.0 ± 0.1
Albuminuria (mg/24 hours)
3.4 ± 1.8
1.1 ± 2.4
3.3 ± 4.8
Creatinine clearance (mL/min)
0.04 ± 0.003
0.03 ± 0.003
0.03 ± 0.008
Data are means ± SE; for each group. Statistically significant at C versus MS ; ; and MS and MSovx + E2 versus MSovx ; ; . C: control; MS: metabolic syndrome; MSovx: metabolic syndrome ovariectomized; MSovx + E2: metabolic syndrome ovariectomized plus estradiol.