Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

Table 1

Comparisons of different histopathological types according to their leptin serum expression.

Analysed groups	Leptin
Malignant versus benign	9.89 ± 0.63 versus 1.92 ± 0.69	<0.001
CPTC versus goiter	9.69 ± 0.89 versus 1.88 ± 0.73	<0.001
CPTC versus FA	9.69 ± 0.89 versus 2.11 ± 0.47	<0.01
CPTC versus FC	9.69 ± 0.89 versus 9.49 ± 0.50	N.S.
FVPTC versus CPTC	10.02 ± 0.57 versus 9.69 ± 0.89	N.S.
FVPTC versus goiter	10.02 ± 0.57 versus 1.88 ± 0.73	<0.001
FVPTC versus FA	10.02 ± 0.57 versus 2.11 ± 0.47	<0.001
FVPTC versus FC	10.02 ± 0.57 versus 9.49 ± 0.50	N.S.
FC versus FA	9.49 ± 0.50 versus 2.11 ± 0.47	<0.001
FC versus goiter	9.49 ± 0.50 versus 1.88 ± 0.73	<0.01
FA versus goiter	2.11 ± 0.47 versus 1.88 ± 0.73	N.S.

CPTC: classic type PTC; FVPTC: follicular variant PTC; FC: follicular carcinoma; AF: follicular adenoma; N.S.: not statistically significant.