Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study
Table 2
Effects of switching to insulin degludec on glycemic control.
Baseline
4 weeks
12 weeks
Fasting plasma glucose (mg/dL)
203.2 ± 81.2
165.5 ± 82.1
206.5 ± 122.4
0.91
HbA1c (%)
8.5 ± 1.4
8.6 ± 1.6
8.7 ± 1.6
0.28
Glycosylated albumin (%)
24.9 ± 5.0
25.3 ± 5.2
24.7 ± 3.6
0.81
Basal insulin dose (U)
15.2 ± 7.6
13.3 ± 6.8
11.6 ± 6.9
<0.01
Bolus insulin dose (U)
24.8 ± 11.1
24.9 ± 11.1
25.6 ± 11.4
0.08
Total daily dose (U)
40.0 ± 17.3
38.1 ± 16.6
37.9 ± 16.7
<0.01
Data are mean ± SD. Between baseline and 12 weeks after switching to insulin degludec by the Mann-Whitney test.
