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International Journal of Endocrinology
Volume 2015, Article ID 194696, 11 pages
http://dx.doi.org/10.1155/2015/194696
Clinical Study

An Intensive Lifestyle Intervention Is an Effective Treatment of Morbid Obesity: The TRAMOMTANA Study—A Two-Year Randomized Controlled Clinical Trial

1Instituto Universitario de Investigación en Ciencias de la Salud (IUNICS), Hospital Universitario Son Espases, Carretera de Valldemossa 79, 07010 Palma de Mallorca, Spain
2Endocrinology and Bariatric Institutes, Cleveland Clinic, 9500 Euclid Avenue M62, Cleveland, OH 44195, USA
3Unidad de Investigación, Hospital Universitario Son Espases, Palma de Mallorca, Spain
4Cirugía General, Hospital Universitario Son Espases, Palma de Mallorca, Spain
5Instituto de Investigación Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, Cátedra UAM-Linde, 28030 Madrid, Spain

Received 5 March 2015; Accepted 18 June 2015

Academic Editor: Francesco Perticone

Copyright © 2015 Bartolomé Burguera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bariatric surgery is currently the most effective therapy to induce weight loss in morbidly obese patients. Objective. This controlled, clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric surgery, on body weight changes and metabolic parameters in morbidly obese patients. Methods. Patients were randomized to an Intensive Lifestyle Intervention (ILI) () or Conventional Obesity Therapy (COT) (). The ILI group received behavioral therapy and nutritional counseling. The COT group received standard medical treatment. They were compared with a third group, Surgical Obesity Group (SOG) (). Results. Patients who received ILI had a greater percentage of weight loss than patients receiving COT (−11.3% versus −1.6%; ). Interestingly 31.4% of patients included in the ILI group were no longer morbidly obese after just six months of intervention, increasing to 44.4% after 24 months of intervention. The percentage weight loss in SOG was −29.6% after that same period of time. Conclusions. ILI was associated with significant weight loss when compared to COT, in a group of patients with obesity. An ILI approach could be an alternative therapy to patients with obesity, who are not candidates to undergo bariatric surgery. This trial is registered with EudraCT 2009-013737-24.