Review Article
The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation
Table 1
GAS6 signaling molecules and the development of obesity in mouse model.
| | Model | Comparison | Treatment | GAS6 (tissue) | Axl (tissue) | Mer (tissue) | Tyro3 (tissue) | Body weight (g) | SC fat weight (mg) | GON fat weight (mg) | References |
| | Axl+/+ mice | Axl+/+ versus WT | | | | | | ↑ (Axl+/+) | | | Augustine et al., 1999 [15] |
| | GAS6−/− mice | GAS6−/− versus WT | | — (GAS6−/−) (SC and GON) | | | | NS | ↓ (GAS6−/−) | ↓ (GAS6−/−) | Maquoi et al., 2005 [3] |
| | GAS6−/− mice | GAS6−/− versus WT | | — (GAS6−/−) (vaginas) | ↑ (GAS6−/−) (vaginas) | ↑ (GAS6−/−) (vaginas) | ↑ (GAS6−/−) (vaginas) | | | |
Salian-Mehta et al., 2014 [28] |
| | C57BL/6 mice | Vehicle versus R428 | R428 oral | versus (ΔCT) (SC) | versus (ΔCT) (SC) | versus (ΔCT) (SC) | versus (ΔCT) (SC) | versus | versus | versus | Lijnen et al., 2011 [16] |
| | C57BL/6 mice | Vehicle versus R428 | R428 oral | versus (ΔCT) (GON) | versus (ΔCT) (GON) | versus (ΔCT) (GON) | versus (ΔCT) (GON) | versus | versus | versus |
Lijnen et al., 2011 [16] |
| | Axl−/− mice | Axl−/− versus WT | SFD | versus (CN) (SC) | versus (CN) (SC) | versus (CN) (SC) | versus (CN) (SC) | versus | versus | | Scroyen et al., 2012 [13] |
| | Axl−/− mice | Axl−/− versus WT | SFD | versus (CN) (GON) | versus (CN) (GON) | versus (CN) (GON) | versus (CN) (GON) | versus | | versus | Scroyen et al., 2012 [13] |
| | Axl−/− mice | Axl−/− versus WT | HFD | versus (CN) (SC) | versus (CN) (SC) | versus (CN) (SC) | versus (CN) (SC) | versus | versus | | Scroyen et al., 2012 [13] |
| | Axl−/− mice | Axl−/− versus WT | HFD | versus (CN) (GON) | versus (CN) (GON) | versus (CN) (GON) | versus (CN) (GON) | versus | | versus | Scroyen et al., 2012 [13] |
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< 0.05; R428, Axl receptor antagonist; SC, subcutaneous fat; GON, gonadal fat; HFD, high-fat diet; SFD, standard fat diet; NS, No significant difference; and CN, copy number.
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