The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation

Table 4

GAS6 signaling molecules and the development of obesity-associated inflammation in clinical studies.

Model	Comparison	Age	GAS6 (plasma, ng/mL)	Axl (plasma, ng/mL)	TNF-α (plasma, ng/mL)	IL-6 (plasma, pg/mL)	hsCRP (plasma, mg/L)	BMI (kg/m^2)	References
T2DM	Normal versus T2DM	versus	versus		versus	versus	versus	versus	Lee et al., 2012 [26], Hung et al., 2010 [17]
T2DM	Normal versus T2DM	versus	versus						Lee et al., 2014 [29]
Human	Male versus female	versus	versus		versus	versus	versus	versus	Kuo et al., 2014 [19]
Female	Pre- versus postmenopausal	versus	versus					versus	Hung et al., 2014 [20]
Adolescents	versus	versus	versus	versus	versus	versus	versus	versus	Hsiao et al., 2013 [11]
Boys with gas6 rs8191974 genotype	GG versus AA		versus		versus	versus	versus	versus	Hsiao et al., 2014 [12]

. T2DM: type 2 diabetes mellitus patients.