Liver Injury Indicating Fatty Liver but Not Serologic NASH Marker Improves under Metformin Treatment in Polycystic Ovary Syndrome

Table 1

Baseline characteristics of patients with PCOS. Comparison of baseline characteristics of PCOS patients with (PCOS-IR) and without IR (PCOS-C). Data were analyzed by -tests, Mann-Whitney test (for BARD-Scores), or Chi²-tests (for dichotomous variables). Values are given as mean ± standard deviation, unless otherwise indicated.

Parameter	PCOS-C; ()	PCOS-IR; ()
HOMA-IR [mmol*mU/L²]	1.4 ± 0.7	4.9 ± 2.6	0.0001
Fasting insulin [µU/mL]	6.3 ± 3.1	20.8 ± 9.9	0.0001
AUCI [mU*h/L]	127 ± 48	300 ± 141	0.0001
Testosterone [nmol/L]	2.5 ± 0.9	2.7 ± 0.8	NS
FAI	4.7 ± 3.3	13.2 ± 16.6	0.001
BMI [kg/m²]	26.8 ± 6.4	35.8 ± 8.5	0.0001
Body weight [kg]	75.9 ± 21.1	101.0 ± 25.0	0.0001
Cholesterol [mg/dL]	186 ± 28	188 ± 33	NS
LDL-cholesterol [mg/dL]	102 ± 22	112 ± 30	NS
HDL-cholesterol [mg/dL]	63 ± 14	48 ± 10	0.0001
Triglycerides [mg/dL]	84 ± 48	161 ± 166	0.002
MBS [%]	5.6	69.8	0.0001
AST [U/L]	25 ± 29	21 ± 6	NS
ALT [U/L]	26 ± 14	30 ± 12	NS
AST/ALT-ratio	0.89 ± 0.3	0.72 ± 0.2	0.002
LIFL [%]	22.2	35.8	NS
BARD-Score [median (25th, 75th percentile)]	2 (0.25, 2.75)	1 (1, 3)	NS
M30 [U/L]	198 ± 91	220 ± 170	NS
NASH [%]	5.6	5.7	NS