The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology

Table 1

Classification of miR-378 variants. Source: miRBase, version 21, September 2015 [28]. The seed sequence (defined as nucleotides 2–8 from the miRNA 5′-end of the mature miRNA) is in bold font.

Name	Mature strand	Previous ID	Sequence	Location	Host gene
Human
hsa-miR-378a	hsa-miR-378a-5p	miR-378	5′-cuccugacuccagguccugugu-3′	chr5: 149732825–149732890	PPARGC1B
	hsa-miR-378a-3p	miR-422b	5′-acuggacuuggagucagaaggc-3′	chr5: 149732825–149732890	PPARGC1B
		miR-378
	hsa-miR-378b	hsa-miR-378b		5′-acuggacuuggaggcagaa-3′	chr3: 10330229–10330285	ATP2B2
hsa-miR-378c	hsa-miR-378c		5′-acuggacuuggagucagaagagugg-3′	chr10: 130962588–130962668	—
hsa-miR-378d-1	hsa-miR-378d		5′-acuggacuuggagucagaaa-3′	chr4: 5923275–5923328	—
hsa-miR-378d-2	hsa-miR-378d		5′-acuggacuuggagucagaaa-3′	chr8: 93916022–93916119	PDP1
hsa-miR-378e	hsa-miR-378e		5′-acuggacuuggagucagga-3′	chr5: 170028488–170028566	DOCK2
hsa-miR-378f	hsa-miR-378f		5′-acuggacuuggagccagaag -3′	chr1: 23929070–23929147	—
hsa-miR-378g	hsa-miR-378g		5′-acugggcuuggagucagaag-3′	chr1: 94745860–94745900	LINC01057
hsa-miR-378h	hsa-miR-378h		5′-acuggacuuggugucagaugg-3′	chr5: 154829458–154829540	FAXDC2
hsa-miR-378i	hsa-miR-378i		5′-acuggacuaggagucagaagg-3′	chr22: 41923222–41923297	TNFRSF13C
hsa-miR-378j	hsa-miR-378j		5′-acuggauuuggagccagaa-3′	chr17: 37614931–37615039	DDX52
Murine
mmu-miR-378a	mmu-miR-378a-5p	miR-378	5′-cuccugacuccagguccugugu-3′	chr18: 61397835–61397900	PPARGC1B
	mmu-miR-378a-3p	miR-378	5′-acuggacuuggagucagaagg-3′	chr18: 61397835–61397900	PPARGC1B
mmu-miR-378b	mmu-miR-378b		5′-cuggacuuggagucagaaga-3′	chr11: 88352773–88352864	MSI2
mmu-miR-378c	mmu-miR-378c		5′-acuggacuuggagucagaagc-3′	chr14: 46954830–46954928	SAMD4
mmu-miR-378d	mmu-miR-378d		5′-acuggccuuggagucagaaggu-3′	chr10: 126710282–126710391	—

The “” sign refers to a nucleotide position not present in the murine and rat miR-378a-3p mature sequence, which is present in the mature human sequence.