|
| miR-378a-3p | miR-378a-5p | Both/unspecified |
| Target | Function | Target | Function | Target | Function |
|
| Metabolism |
| NRF1 [42] | Critical regulator of the mitochondrial function | CYP2E1 [41] | Involved in conversion of acetyl-CoA to glucose | cEBPα [27] | Transcription factor, promotes expression of leptin |
| TPM2 [44] | Involved in the regulation of ATPase activity | ERRγ [5] | Involved in control of oxidative metabolism | cEBPβ [27] | Transcription factor, regulation of genes involved in immune and inflammatory responses |
| IGF1R [57] | Tyrosine kinase receptor, mediates the effects of IGF-1 | GABPα [5] | Involved in control of oxidative metabolism, nuclear control of mitochondrial function | | |
| RORA [69] | Orphan receptor, possibly involved in circadian rhythm | GDP [67] | Enzyme involved in GDP-mannose production | | |
| LDHA [44] | Involved in the lactic acid cycle | DDAH [44] | Involved in the synthesis of arginine from citrulline | | |
| CRAT [6]# | Catalyzes exchange of acyl groups between carnitine and coenzyme A | LDHA [44] | Involved in the lactic acid cycle | | |
| | | MED13 [6] | Component of the mediator complex (transcriptional coactivator) | | |
|
| Muscle differentiation and regeneration |
| MyoR [7] | Represses MyoD (and thus myogenesis) | VIM [44] | Cytoskeletal protein anchoring position of organelles | Purβ [69] | Controlling transcription of smooth muscle actin |
| ACTN4 [44] | Nonmuscle α-actinin isoform, cytoskeletal protein | Actin [44] | Cytoskeletal protein, involved in muscle contraction | | |
| 14-3-3-γ [44] | Regulatory protein highly expressed in muscle | Hsp70.3 [76] | Involved in cytoprotective responses against stress induced stimuli | | |
| CASP3 [73]® | Involved in activation of apoptosis | | | | |
| CTGF [74] | Connective tissue growth factor | | | | |
| TGFβ1 [74] | Involved in cell growth, proliferation, differentiation, and apoptosis | | | | |
| IGF1R [57] | Tyrosine kinase receptor, mediates the effects of IGF-1 | | | | |
| MAPK [77, 78] | Involved in proliferation, differentiation cell survival, and apoptosis | | | | |
|
| Angiogenesis |
| TOB2 [88] | Suppressing cyclin D1 | VEGF-A [89] | Induction of angiogenesis | | |
| | | SuFu [8] | Involved in inhibition of SHH pathway | | |
| | | Fus-1 [8] | Involved in RNA binding and tumor suppression | | |
| | | FN1 [112] | Receptor binding integrin | | |
| | | BAX [93] | Involved in apoptosis, activation of caspases | | |
| | | ITGB3 [116] | Involved in cell adhesion and cell-surface signaling | | |
| | | VIM [116] | Involved in anchoring position of organelles | | |
|
