Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice

Figure 2

FGF21 stimulates mediators of oxidative stress resistance. RT-PCR analysis of gene expression in normal and GH transgenic mice treated with FGF21 (mean ± SEM) of the following genes: (a) superoxide dismutase 2, (b) catalase, (c) glutathione peroxidase, (d) sirtuin 1, and (e) Forkhead box class O, 3. Different superscripts denote significant difference at (2-tailed, unpaired, homoscedastic Student’s -test).

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