Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice
Table 3
FGF21-induced effects on genes for hypothalamic neuropeptides.
Gene of interest
N-PBS
N-FGF21
Tg-PBS
Tg-FGF21
AgRP
1 ± 0.11
1.17 ± 0.08
0.93 ± 0.21
0.86 ± 0.10
POMC
1 ± 0.17
1.22 ± 0.09
1.04 ± 0.09
1.32 ± 0.14
CART
1 ± 0.01
1.01 ± 0.08
0.92 ± 0.11
1.08 ± 0.03
NPY
1 ± 0.06
1.04 ± 0.02
1.14 ± 0.13
1.17 ± 0.09
MCH
1 ± 0.12
0.95 ± 0.08
1.12 ± 0.04
1.26 ± 0.09
Orexin
1 ± 0.10
1.17 ± 0.12
1.09 ± 0.05
1.21 ± 0.14
LEPR
1 ± 0.12
1.21 ± 0.07
1.49 ± 0.29
1.77 ± 0.33
Shown is RT-PCR analysis of gene expression in normal and GH transgenic mice treated with FGF21 and vehicle (mean ± SEM, = 5).
