Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism

Table 2

Parameters in short-stature children with PPH accompanied by low GH levels before and after 3 months of L-T₄ therapy.

Parameters	Before L-T4 therapy ()	After L-T4 therapy ()	value
HtSDS	−2.96 ± 0.73	−2.51 ± 0.96	0.006
BMI	22.14 ± 5.91	19.09 ± 4.46	0.004
FT3 (pmol/L)	2.2 ± 2.0	7.6 ± 1.8	<0.001
FT4 (pmol/L)	4.1 ± 2.1	20.4 ± 4.5	<0.001
TSH (mIU/L)	>50.0	1.9 ± 2.0	<0.001
IGF-1 (ng/mL)	100.91 ± 35.36	129.74 ± 46.07	0.004
PRL (g/L)	40.6 ± 16.7	8.7 ± 3.1	<0.001
Pituitary height (mm)	14.3 ± 3.8	5.4 ± 1.5	<0.001

PPH: pituitary hyperplasia secondary to primary hypothyroidism; GH: growth hormone; L-T₄: levothyroxine; HtSDS: height standard deviation scores; BMI: body mass index; FT₃: free triiodothyronine; FT₄: free thyroxine; TSH: thyrotropin; IGF-1: insulin-like growth factor-1; PRL: prolactin.