Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action

Table 1

Summary of meta-analysis results regarding the association between androgen receptor CAG repeat and prostate cancer.

Meta-analysis	Number of studies included	Cases/controls	Opposite relation between CAG length and prostate cancer risk; (yes/no)	Remarks
Zeegers et al. [36]	19	4274/5275	Yes	Modest association between shorter repeats and prostate cancer risk
Gu et al. [37]	27	2972/3792, 3835/4908, and 3372/2631 for comparisons of ≥20, 22, and 23 repeats of CAG sequence with others	Yes	AR CAG repeat polymorphism with ≥20 repeats might confer a protective effect among the prostate cancer patients older than 45 years but not all the prostate cancer patients
Sun and Lee [38]	47	13346/15172	Yes	Shorter CAG repeat sequence had an increased risk of prostate cancer (OR 1.21, 95% CI 1.10–1.34) regardless of the exact length of the CAG repeat, compared with carriers of a longer repeat sequence

OR: odds ratio; AR: androgen receptor.