Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients

Table 1

Grading of mitral valve characteristics according to Wilkins score.

Grade	Mobility	Thickening	Calcification	Subvalvular thickening
1	Highly mobile valve with only 1 leaflet tips restricted	Leaflets near normal in thickness (4-5 mm)	A single area of increased echo brightness	A single area of increased echo brightness
2	Leaflet midportions and base portions have normal mobility	Midleaflets normal, considerable thickening of margins (5–8 mm)	Scattered areas of brightness confined to leaflet margins	Scattered areas of brightness confined to leaflet margins
3	Valve continues to move forward in diastole, mainly from the base	Thickening extending through the entire leaflet (5–8 mm)	Brightness extending into the midportion of the leaflets	Thickening extending to the distal third of the chords
4	No or minimal forward movement of the leaflets in diastole	Considerable thickening of all leaflet tissue (>8–10 mm)	Extensive brightness throughout much of the leaflet tissue	Extensive thickening and shortening