Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2015 (2015), Article ID 321901, 6 pages
http://dx.doi.org/10.1155/2015/321901
Research Article

Ejaculate Oxidative Stress Is Related with Sperm DNA Fragmentation and Round Cells

Humanitas Fertility Center, Department of Gynaecology, Division of Gynecology and Reproductive Medicine, Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy

Received 10 November 2014; Revised 13 January 2015; Accepted 15 January 2015

Academic Editor: Małgorzata Kotula-Balak

Copyright © 2015 Valeria Maria Iommiello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Aitken and G. N. de Iuliis, “On the possible origins of DNA damage in human spermatozoa,” Molecular Human Reproduction, vol. 16, no. 1, Article ID gap059, pp. 3–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Hwang and J. D. Lamb, “Molecular mechanisms of male infertility,” in Male Infertility, S. J. Parekattil and A. Agarwal, Eds., Springer, New York, NY, USA, 2012. View at Google Scholar
  3. R. Henkel, E. Kierspel, T. Stalf et al., “Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients,” Fertility and Sterility, vol. 83, no. 3, pp. 635–642, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Cocuzza, S. C. Sikka, K. S. Athayde, and A. Agarwal, “Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis,” International Brazilian Journal of Urology, vol. 33, no. 5, pp. 603–621, 2007. View at Google Scholar
  5. G. Aktan, S. Doğru-Abbasoğlu, C. Küçükgergin, A. Kadıoğlu, G. Ozdemirler-Erata, and N. Koçak-Toker, “Mystery of idiopathic male infertility: is oxidative stress an actual risk?” Fertility and Sterility, vol. 99, no. 5, pp. 1211–1215, 2013. View at Publisher · View at Google Scholar
  6. M. Cocuzza, K. S. Athayde, A. Agarwal et al., “Age related increase of reactive oxygen species in neat semen in healthy fertile men,” Urology, vol. 71, no. 3, pp. 490–494, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. A. Saleh and A. Agarwal, “Oxidative stress and male infertility: from research bench to clinical practice,” Journal of Andrology, vol. 23, no. 6, pp. 737–752, 2002. View at Google Scholar · View at Scopus
  8. R. J. Aitken, “The roe of free oxygen radicals and sperm function,” International Journal of Andrology, vol. 12, no. 2, pp. 95–97, 1989. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Ozmen, N. Koutlaki, M. Youssry, K. Diedrich, and S. Al-Hasani, “DNA damage of human spermatozoa in assisted reproduction: origins, diagnosis, impacts and safety,” Reproductive BioMedicine Online, vol. 14, no. 3, article 2730, pp. 384–395, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. R. T. Schulte, D. A. Ohl, M. Sigman, and G. D. Smith, “Sperm DNA damage in male infertility: etiologies, assays, and outcomes,” Journal of Assisted Reproduction and Genetics, vol. 27, no. 1, pp. 3–12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. R. J. Aitken, M. A. Baker, and D. Sawyer, “Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease,” Reproductive BioMedicine Online, vol. 7, no. 1, pp. 65–70, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Moustafa, R. K. Sharma, J. Thornton et al., “Relationship between ROS production, apoptosis and DNA denaturation in spermatozoa from patients examined for infertility,” Human Reproduction, vol. 19, no. 1, pp. 129–138, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Novotny, N. Aziz, R. Rybar et al., “Relationship between reactive oxygen species production in human semen and sperm DNA damage assessed by Sperm Chromatin Structure Assay,” Biomedical Papers, vol. 157, no. 4, pp. 383–386, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Jones, T. Mann, and R. Sherins, “Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma,” Fertility and Sterility, vol. 31, no. 5, pp. 531–537, 1979. View at Google Scholar · View at Scopus
  15. R. J. Aitken and J. S. Clarkson, “Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa,” Journal of Reproduction and Fertility, vol. 81, no. 2, pp. 459–469, 1987. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Greco, M. Iacobelli, L. Rienzi, F. Ubaldi, S. Ferrero, and J. Tesarik, “Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment,” Journal of Andrology, vol. 26, no. 3, pp. 349–353, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. J. R. Ménézo, A. Hazout, G. Panteix et al., “Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect,” Reproductive BioMedicine Online, vol. 14, no. 4, article 2669, pp. 418–421, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Greco, S. Romano, M. Iacobelli et al., “ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment,” Human Reproduction, vol. 20, no. 9, pp. 2590–2594, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Aydemir, I. Onaran, A. R. Kiziler, B. Alici, and M. C. Akyolcu, “The influence of oxidative damage on viscosity of seminal fluid in infertile men,” Journal of Andrology, vol. 29, no. 1, pp. 41–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Wang, C.-L. Liang, J.-Q. Wu, C. Xu, S.-X. Qin, and E.-S. Gao, “Do Ureaplasma urealyticum infections in the genital tract affect semen quality?” Asian Journal of Andrology, vol. 8, no. 5, pp. 562–568, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. R. J. Aitken and M. A. Baker, “Oxidative stress, spermatozoa and leukocytic infiltration: relationships forged by the opposing forces of microbial invasion and the search for perfection,” Journal of Reproductive Immunology, vol. 100, no. 1, pp. 11–19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Menkveld, “Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen,” Asian Journal of Andrology, vol. 12, no. 1, pp. 47–58, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Zini, R. Bielecki, D. Phang, and M. T. Zenzes, “Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men,” Fertility and Sterility, vol. 75, no. 4, pp. 674–677, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. B. J. M. Mayorga-Torres, W. Cardona-Maya, Á. Cadavid, and M. Camargo, “Evaluation of sperm functional parameters in normozoospermic infertile individuals,” Actas Urologicas Espanolas, vol. 37, no. 4, pp. 221–227, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. World Health Organization, WHO Laboratory Manual for Examination and Processing of Human Semen, WHO Press, Geneva, Switzerland, 5th edition, 2010.
  26. R. L. Baehner, L. A. Boxer, and J. Davis, “The biochemical basis of nitroblue tetrazolium reduction in normal human and chronic granulomatous disease polymorphonuclear leukocytes,” Blood, vol. 48, no. 2, pp. 309–313, 1976. View at Google Scholar · View at Scopus
  27. H. S. Choi, J. W. Kim, Y. N. Cha, and C. Kim, “A quantitative nitroblue tetrazolium assay for determining intracellular superoxide anion production in phagocytic cells,” Journal of Immunoassay & Immunochemistry, vol. 27, no. 1, pp. 31–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Esfandiari, R. K. Sharma, R. A. Saleh, A. J. Thomas Jr., and A. Agarwal, “Utility of the nitroblue tetrazolium reduction test for assesment of reactive oxigen species production by seminal leukocytes and spermatozoa,” Journal of Andrology, vol. 24, no. 6, pp. 862–870, 2003. View at Google Scholar · View at Scopus
  29. D. P. Evenson, K. L. Larson, and L. K. Jost, “Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques,” Journal of Andrology, vol. 23, no. 1, pp. 25–43, 2001. View at Google Scholar · View at Scopus
  30. A. Agarwal, G. Virk, C. Ong, and S. S. Du Plessis, “Effect of oxidative stress on male reproduction,” The World Journal of Men's Health, vol. 32, no. 1, pp. 1–17, 2014. View at Publisher · View at Google Scholar
  31. O. Tunc, J. Thompson, and K. Tremellen, “Development of the NBT assay as a marker of sperm oxidative stress,” International Journal of Andrology, vol. 33, no. 1, pp. 13–21, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. D. S. Guzick, J. W. Overstreet, P. Factor-Litvak et al., “Sperm morphology, motility, and concentration in fertile and infertile men,” The New England Journal of Medicine, vol. 345, no. 19, pp. 1388–1393, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. J. P. E. Bonde, E. Ernst, T. K. Jensen et al., “Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners,” The Lancet, vol. 352, no. 9135, pp. 1172–1177, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. R. J. Aitken, E. Gordon, D. Harkiss et al., “Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa,” Biology of Reproduction, vol. 59, no. 5, pp. 1037–1046, 1998. View at Publisher · View at Google Scholar · View at Scopus
  35. R. J. Aitken and C. Krausz, “Oxidative stress, DNA damage and the Y chromosome,” Reproduction, vol. 122, no. 4, pp. 497–506, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. R. K. Sharma, F. F. Pasqualotto, D. R. Nelson, J. Thomas A.J., and A. Agarwal, “Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic,” Journal of Andrology, vol. 22, no. 4, pp. 575–583, 2001. View at Google Scholar · View at Scopus
  37. F. F. Pasqualotto, R. K. Sharma, H. Kobayashi, D. R. Nelson, A. Thomas Jr., and A. Agarwal, “Oxidative stress in normospermic men undergoing infertility evaluation,” Journal of Andrology, vol. 73, pp. 459–464, 2001. View at Google Scholar