Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes
Table 2
Relationships between serum Mg with renal function and bone metabolism parameters in CKD patients with or without diabetes.
Dependent variables
Mg (mg/dL)
(pg/mL)
95% CI for
95% CI for
With diabetes
Renal function indicators
(mL/min)
−1.616
−0.473
0.014
(−2.869, −0.363)
−0.191
−0.282
0.220
(−0.504, 0.122)
(mg/dL)
1.539
0.528
0.007
(0.461, 2.616)
0.175
0.175
0.202
(−0.101, 0.451)
(mg/dL)
0.952
0.391
0.044
(0.026, 1.878)
0.027
0.056
0.810
(−0.202, 0.255)
Bone metabolism parameters‡
(pg/mL)
2.296
0.454
0.041
(0.109, 4.483)
(mg/dL)
−0.134
−0.546
0.015
(−0.239, −0.028)
−0.030
−0.626
0.003
(−0.049, −0.012)
(mg/dL)
0.272
0.312
0.106
(−0.063, 0.608)
0.040
0.231
0.222
(−0.026, 0.106)
(U/L)
0.719
0.449
0.027
(0.093, 1.345)
0.168
0.529
0.005
(0.056, 0.279)
(ng/mL)
−0.369
−0.221
0.420
(−1.305, 0.567)
−0.188
−0.570
0.023
(−0.348, −0.029)
(pg/mL)
−0.286
−0.081
0.745
(−2.094, 1.523)
−0.077
−0.110
0.649
(−0.422, 0.269)
Without diabetes
Renal function indicators
(mL/min)
−1.091
−0.381
0.034
(−2.092, −0.090)
0.040
0.084
0.665
(−0.150, 0.231)
(mg/dL)
0.922
0.404
0.040
(0.046, 1.798)
−0.045
−0.119
0.577
(−0.210, 0.120)
(mg/dL)
0.426
0.172
0.368
(−0.531, 1.382)
−0.020
−0.047
0.814
(0.814, 0.149)
Bone metabolism parameters
(pg/mL)
1.057
0.176
0.413
(−1.566, 3.679)
(mg/dL)
−0.153
−0.407
0.068
(−0.318, 0.012)
0.007
0.118
0.597
(−0.021, 0.026)
(mg/dL)
0.148
−0.135
0.508
(−0.605, 0.308)
−0.065
−0.355
0.065
(−0.134, −0.004)
(U/L)
0.221
0.155
0.469
(−0.400, 0.841)
0.085
0.357
0.078
(−0.010, 0.179)
(ng/mL)
−1.250
−0.580
0.002
(−1.993, −0.507)
−0.079
−0.219
0.273
(−0.223, 0.066)
(pg/mL)
0.895
0.255
0.245
(−0.656, 2.446)
0.107
0.183
0.392
(−0.147, 0.362)
(1) eGFR, estimated glomerular filtration rate; BUN, blood urine nitrogen; iPTH, intact parathyroid hormone; ALP, alkaline phosphatase; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)2D, 1,25-dihydroxyvitamin D. (2) All outcomes of the multiple regression analysis are presented in unstandardized coefficients () and standardized coefficients () and at a 95% confidence interval (CI) for . A value less than 0.05 was considered statistically significant. Adjusted gender and age. Adjusted gender, age, albumin, and eGFR.
