Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives

<div>The biosynthesis of vitamin D and the major effects 1<i>α</i>,25(OH)<sub>2</sub>D<sub>3</sub> has on different organs. Synthesis begins in the skin before activation in the liver and kidneys. PTH: parathyroid hormone, Ca: calcium, and <svg height="11.5695pt" id="M3" style="vertical-align:-3.18152pt" version="1.1" viewbox="-0.0498162 -8.38798 10.4561 11.5695" width="10.4561pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M46 650V622C120 617 128 613 128 525V125C128 42 120 34 40 28V0H311V28C221 34 212 39 212 124V281L286 262C297 261 316 261 331 263C429 275 526 338 526 468C526 533 501 579 462 609C422 638 364 650 293 650H46ZM212 559C212 588 215 600 223 606C230 613 251 618 279 618C361 618 430 572 430 464C430 337 350 302 285 302C252 302 225 309 212 314V559Z" id="g121-78"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="563" vert-adv-y="563"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.319,3.132)"><path d="M138 535C169 535 191 560 191 589C191 620 168 644 139 644S85 620 85 589C85 560 110 535 138 535ZM257 0V30C192 35 185 43 185 109V453C142 435 94 422 40 414V386C101 378 104 372 104 311V109C104 41 97 35 33 30V0H257Z" id="g58-103"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="275" vert-adv-y="275"></glyph.data></g></svg>: inorganic phosphate.</div>

International Journal of Endocrinology

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Figure 1

Figure 1: Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives 