Low intake and serum Vit D ≠ ↑ risk for progression of knee OA Vit D positively correlated with BMD, Vit D intake, and physical activity Vit D inversely correlated with BMI Low Vit D = increased risk of knee OA Vit D levels predict osteophyte growth and cartilage loss (less so)
Participants of the Osteoporotic Fractures in Men Study (MrOS)
77.2 ± 5.3
↑ 25(OH)D levels = ↓ prevalence of radiographic hip OA Vit D insufficient men (levels of 25[OH]D 15.1–30 ng/mL) = 2-fold ↑ likelihood of prevalent radiographic hip OA compared with Vit D sufficient men
↓ 25(OH)D in OA than control (NS) High prevalence rate of serum 25-OHD deficiency Significant positive association between serum 25(OH)D deficiency and knee OA in a subgroup of patients aged <60 years, greater association in younger patients
Participants of the Tasmanian Older Adult Cohort Study (TASOAC); did not have RA
Baseline Vit D insuff. = ↓ knee cartilage (medial and lateral tibial sites), regardless of sex, ROA status, and knee pain Baseline Vit D levels predicted changes in medial and lateral tibial cartilage volume ↑ Serum 25(OH)D levels = ↑ knee tibial cartilage volume in older people, particularly in females, ROA patients, and those with knee pain Vit D insuff. = moderate-to-severe JSN in older adults
Baseline Vit D ≠ radiographic worsening ↑ Vit D = slightly ↑ rates of worsening (NS after adjustment for risk factors) Vit D def. = slight ↑ in risk of JSN (NS after adjustment for risk factors) ↓ Vit D = slight ↓ risk of osteophyte growth
Baseline Vit D ≠ radiographic worsening ↑ Vit D = ↑ risk of worsening No Vit D def. = slight ↑ risk of JSN (NS after adjustment for risk factors) ↓ Vit D ≠ osteophyte growth Vit D def. appears slightly protective against cartilage loss
Vit D def. = quadriceps dysfunction but ≠ inflammatory cytokines
† means at baseline in longitudinal studies. Vit D: vitamin D; ROA: radiographic osteoarthritis; ACR: American College of Rheumatology; NS: not statistically significant; BMI: body mass index; BMD: bone mineral density; HPLC: high performance liquid chromatography; ELISA: enzyme-linked immunosorbent assay; MS: mass spectrometry; Insuff.: insufficient; Def.: deficient; ↓: lower/decreased; ↑: higher/increased; ≠: no association; =: association; yrs: years; mo: months; we: weeks; JSN: joints space narrowing; N/A: not applicable.
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