International Journal of Endocrinology / 2015 / Article / Tab 4

Review Article

Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives

Table 4

Summaries of randomised clinical trials to assess the efficacy of vitamin D supplementation for the treatment of knee osteoarthritis.

ReferenceCountrySupplementDoseCondition of samplesVitamin D status of participantsSamples/placeboVitamin D assayFollow-upResults

Sanghi et al. [28] 2013IndiaCholecalciferol granules or placebo60,000 IU per day for 10days followed by 60,000 IU once a month for 12 months>40 yrs old
ACR Criteria
WOMAC pain >4 for at least 6 months
6 months of conventional treatment
BMI <30
No previous fracture or surgery to knee
Vitamin D insufficiency (25(OH)D ≤ 50 nmol/L)52/51EIAMultiple over a 12-month periodVit D = ↓ VAS and WOMAC pain scores versus placebo
Vit D = ↓ WOMAC physical + total versus placebo
Vit D = ↑ serum calcium, 25(OH)D, and alkaline phosphatase versus placebo
No difference in WOMAC stiffness

McAlindon et al. [29] 2013USACholecalciferol or placebo2,000 IU daily with subsequent adjustment in 2000 IU increments at 4, 8, and 12 months for a target 25OHD level between 36 and 100 ng/mLAge > 45
Symptomatic knee OA
KL ≥ 2 (ACR Criteria) WOMAC = mild pain
Not selected for73/73LC/MS/MSMultiple over a 24-month periodVit D levels ↑ over the 2 years
No significant difference in knee pain between groups
No significant differences between cartilage loss, JSW, and BML size
No significant difference in WOMAC pain or function scores

Vit D: vitamin D; BMI: body mass index; ↑: higher/increased; =: association; ACR: American College of Rheumatology; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; KL: Kellgren-Lawrence grading; VAS: visual analogue score; JSW: joint space width; BML: bone marrow lesion; EIA: enzyme immunoassay; LC/MS/MS: liquid chromatography-tandem mass spectrometry.

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