Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice

Figure 3

Atherosclerotic lesions in each treatment group. (a) Representative histological sections of aortic sinus stained with oil red O at 15 weeks after treatment. The area of oil red O-positive lesions in the aortic wall was evaluated. (b) Representative histological sections of the entire aorta stained with oil red O at 15 weeks after treatment. The area of oil red O-positive lesions in the entire aorta was evaluated. Data are mean ± SEM. versus the glucose group by Student’s -test. C group: control group (), G group: glucose group (-21), G + Ipra group: glucose plus ipragliflozin group (), I group: insulin group (-17), and G + Ins group: glucose plus insulin group (-20).

(a)

(b)