Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice
Table 4
Plasma glucose levels after intraperitoneal injection of saline or insulin in each group.
Control group
Glucose group
Glucose + ipragliflozin group
Insulin group
Glucose + insulin group
Day 22
Glucose level (mmol/L) after administration
0 min
9.4 ± 0.2
9.5 ± 0.2
10.2 ± 0.3
9.7 ± 0.2
10.0 ± 0.3
15 min
9.4 ± 0.4
17.2 ± 0.7
15.2 ± 0.5
5.5 ± 0.2
7.0 ± 0.2
30 min
11.6 ± 0.4
14.8 ± 1.0
14.6 ± 0.4
5.0 ± 0.2
5.1 ± 0.2
45 min
12.6 ± 0.6
13.0 ± 0.7
13.3 ± 0.4
4.8 ± 0.2
5.0 ± 0.2
60 min
12.5 ± 0.4
12.8 ± 0.8
13.0 ± 0.3
4.3 ± 0.3
4.4 ± 0.2
90 min
11.5 ± 0.3
11.9 ± 0.6
10.8 ± 0.3
3.5 ± 0.5
3.1 ± 0.2
Day 92
Glucose level (mmol/L) after administration
0 min
8.8 ± 0.1
9.1 ± 0.2
8.6 ± 0.3
8.9 ± 0.2
9.0 ± 0.2
15 min
10.2 ± 0.4
16.9 ± 0.9
14.2 ± 0.8
5.2 ± 0.2
8.7 ± 1.1
30 min
11.4 ± 0.4
14.7 ± 0.7
12.5 ± 0.8
4.7 ± 0.2
6.0 ± 0.7
45 min
12.6 ± 0.3
13.5 ± 0.7
12.0 ± 0.7
4.4 ± 0.2
5.9 ± 1.1
60 min
12.9 ± 0.6
14.2 ± 0.8
12.1 ± 0.7
3.8 ± 0.2
5.8 ± 1.3#†
90 min
11.6 ± 0.5
12.4 ± 0.6
10.2 ± 0.7
3.2 ± 0.6
4.5 ± 1.1
Data are mean ± SEM. versus control, # versus glucose, † versus ipragliflozin, and versus insulin. Mice received intraperitoneal injections of 10 mL/kg saline (control group, glucose group, and glucose + ipragliflozin group) or injections of 8 IU/kg insulin (insulin group and glucose + insulin group).
