International Journal of Endocrinology / 2015 / Article / Tab 2

Research Article

Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression

Table 2

Associations between labour associated inflammatory genes (PTGS2, BMP2, NAMPT, and CXCL2) and steroid receptor genes (PGR, ESR1, and NR3C1) allele hypermethylation and the percentage of gene alleles that were hypermethylated in ACE, AGTR1, ATP6AP2, CTSD, and KLK1 in amnion and decidua.

ACE1 AGTR1 ATP6AP2 CTSD KLK1

Amnion
PTGS2 r = 0.85r = 0.81r = 0.50r = 0.60ns
P < 0.001P < 0.001P = 0.036P < 0.01
BMP2 r = 0.83r = 0.90r = 0.57r = 0.82ns
P < 0.001P < 0.001P = 0.017P < 0.001
NAMPT r = 0.71r = 0.72nsr = 0.68ns
P < 0.001P < 0.001P = 0.001
CXCL2 r = 0.94r = 0.80r = 0.69r = 0.56ns
P < 0.001P < 0.001P = 0.002P = 0.013
NR3C1 r = 0.72r = 0.78r = 0.49r = 0.49ns
P < 0.001P < 0.001P = 0.035P = 0.03
PGR r = 0.85r = 0.83r = 0.53r = 0.71ns
P < 0.001P < 0.001P = 0.02P < 0.001
ESR1 r = 0.87r = 0.77r = 0.71r = 0.49ns
P < 0.001P < 0.001P = 0.001P = 0.038

Decidua
PTGS2 r = 0.75r = 0.72nsr = 0.86ns
P = 0.001P = 0.003P < 0.001
BMP2 r = 0.90r = 0.90r = 0.62r = 0.84ns
P < 0.001P < 0.001P = 0.033P < 0.001
NAMPT r = 0.55nsnsr = 0.83ns
P = 0.04P < 0.001
CXCL2 r = 0.88r = 0.82r = 0.78r = 0.77ns
P < 0.001P < 0.001P = 0.001P = 0.001
NR3C1 nsnsnsnsns
PGR r = 0.93r = 0.94r = 0.71r = 0.87ns
P < 0.001P < 0.001P = 0.005P < 0.001
ESR1 r = 0.72r = 0.80nsr = 0.83ns
P = 0.003P < 0.001P < 0.001

ns = not significant.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.