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International Journal of Endocrinology
Volume 2015, Article ID 534320, 13 pages
http://dx.doi.org/10.1155/2015/534320
Review Article

Differential Role of Leptin and Adiponectin in Cardiovascular System

1Department of Anatomy, Cell biology and Physiology, American University of Beirut, DTS-255, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
2Department of Pharmacology and Toxicology, American University of Beirut, DTS-255, P.O. Box 11-0236, Beirut 1107-2020, Lebanon

Received 7 December 2014; Accepted 23 April 2015

Academic Editor: Alexander Schreiber

Copyright © 2015 C. M. Ghantous et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [67 citations]

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  • Nicole M. Cancelliere, Emily A. E. Black, and Alastair V. Ferguson, “Neurohumoral Integration of Cardiovascular Function by the Lamina Terminalis,” Current Hypertension Reports, vol. 17, no. 12, 2015. View at Publisher · View at Google Scholar
  • Qin Dong, Na Li, Qi Li, Cong-En Zhang, Wu-Wen Feng, Guang-Quan Li, Rui-Yu Li, Can Tu, Xue Han, Zhao-Fang Bai, Ya-Ming Zhang, Ming Niu, Zhi-Jie Ma, Xiao-He Xiao, and Jia-Bo Wang, “Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study,” Frontiers in Pharmacology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Crystal M. Ghantous, Firas H. Kobeissy, Nadia Soudani, Farah A. Rahman, Mustafa Al-Hariri, Hana A. Itani, Ramzi Sabra, and Asad Zeidan, “Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation,” Frontiers in Pharmacology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Magdalena Luczak, Dorota Formanowicz, Łukasz Marczak, Joanna Suszyńska-Zajczyk, Elżbieta Pawliczak, Maria Wanic-Kossowska, and Maciej Stobiecki, “iTRAQ-based proteomic analysis of plasma reveals abnormalities in lipid metabolism proteins in chronic kidney disease-related atherosclerosis,” Scientific Reports, vol. 6, pp. 32511, 2016. View at Publisher · View at Google Scholar
  • Maria A.C. Jansen, Cuno S.P.M. Uiterwaal, Frank L.J. Visseren, Cornelis K. van der Ent, Diederick E. Grobbee, and Geertje W. Dalmeijer, “Abdominal fat and blood pressure in healthy young children,” Journal of Hypertension, vol. 34, no. 9, pp. 1796–1803, 2016. View at Publisher · View at Google Scholar
  • António Albino-Teixeira, Joana Afonso, António Guerra, Alberto C. Afonso, Liane Correia-Costa, Ana Azevedo, Teresa Sousa, Manuela Morato, Dina Cosme, José C. Areias, and Franz Schaefer, “Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function,” British Journal of Nutrition, vol. 116, no. 5, pp. 805–815, 2016. View at Publisher · View at Google Scholar
  • Nadia Soudani, Crystal M. Ghantous, Zein Farhat, Wassim N. Shebaby, Kazem Zibara, and Asad Zeidan, “Calcineurin/NFAT Activation-Dependence of Leptin Synthesis and Vascular Growth in Response to Mechanical Stretch,” Frontiers in Physiology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Itamar S Santos, Paulo A Lotufo, Isabela M Bensenor, and Sandra RG Ferreira, “Association between carotid intima-media thickness and adiponectin in participants without diabetes or cardiovascular disease of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil),” European Journal of Preventive Cardiology, vol. 24, no. 2, pp. 116–122, 2016. View at Publisher · View at Google Scholar
  • V.P. Puurunen, E.S. Lepojärvi, O.P. Piira, P. Hedberg, M.J. Junttila, O. Ukkola, and H.V. Huikuri, “High plasma leptin levels are associated with impaired diastolic function in patients with coronary artery disease,” Peptides, 2016. View at Publisher · View at Google Scholar
  • Verena Brüll, Constanze Burak, Birgit Stoffel-Wagner, Siegfried Wolffram, Georg Nickenig, Cornelius Müller, Peter Langguth, Birgit Alteheld, Rolf Fimmers, Peter Stehle, and Sarah Egert, “No effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight-to-obese patients with (pre-)hypertension: a randomized double-blinded, placebo-controlled crossover trial,” European Journal of Nutrition, 2016. View at Publisher · View at Google Scholar
  • Lin Zhao, Chongxi Fan, Yu Zhang, Yang Yang, Dongjin Wang, Chao Deng, Wei Hu, Zhiqiang Ma, Shuai Jiang, Shouyi Di, Zhigang Qin, Jianjun Lv, Yang Sun, and Wei Yi, “Adiponectin enhances bone marrow mesenchymal stem cell resistance to flow shear stress through AMP-activated protein kinase signaling,” Scientific Reports, vol. 6, pp. 28752, 2016. View at Publisher · View at Google Scholar
  • Chi-Yeon Park, Seung-Cheol Choi, Sang-Keun Woo, Jung Woo Yu, Gi Jeong Cheon, Hyung Joon Joo, Jong-Ho Kim, Do-Sun Lim, Soon Jun Hong, and Jae Hyung Park, “Intramyocardial adipose-derived stem cell transplantation increases pericardial fat with recovery of myocardial function after acute myocardial infarction,” PLoS ONE, vol. 11, no. 6, 2016. View at Publisher · View at Google Scholar
  • Wared Nour-Eldine, Crystal M. Ghantous, Kazem Zibara, Leila Dib, Hawraa Issaa, Hana A. Itani, Nabil El-Zein, and Asad Zeidan, “Adiponectin Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Remodeling through Nitric Oxide and the RhoA/ROCK Pathway,” Frontiers in Pharmacology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Yingmei Zhang, and Jun Ren, “Epigenetics and Obesity Cardiomyopathy: From Pathophysiology to Prevention and Management,” Pharmacology & Therapeutics, 2016. View at Publisher · View at Google Scholar
  • Leyla Karkhaneh, Parichehreh Yaghmaei, Kazem Parivar, Majid Sadeghizadeh, and Azadeh Ebrahim-Habibi, “Effect of trans-chalcone on atheroma plaque formation, liver fibrosis and adiponectin gene expression in cholesterol-fed NMRI mice,” Pharmacological Reports, 2016. View at Publisher · View at Google Scholar
  • Jihui Zhang, Junling Fu, Heng Wu, Yonghui Wang, Lujiao Li, Yanglu Zhao, Ming Li, Dan Feng, and Shan Gao, “Association between sleep duration and cardiac structure in youths at risk for metabolic syndrome,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Giovana Jamar, Danielle Arisa Caranti, Helena de Cassia Cesar, Deborah Cristina Landi Masquio, Daniel Henrique Bandoni, and Luciana Pellegrini Pisani, “Leptin as a cardiovascular risk marker in metabolically healthy obese,” Appetite, 2016. View at Publisher · View at Google Scholar
  • Anne Briançon-Marjollet, Marion Henri, Marie Joyeux-Faure, Perle Totoson, Diane Godin-Ribuot, Denis Monneret, Sandrine Cachot, and Patrice Faure, “Intermittent hypoxia in obese Zucker rats: cardiometabolic and inflammatory effects,” Experimental Physiology, vol. 101, no. 11, pp. 1432–1442, 2016. View at Publisher · View at Google Scholar
  • Xing-Heng Wu, Li-Na Zhang, and Dan-Dan Wu, “Effect of leptin on expression of calpain-1 and Bcl-2 and apoptosis in myocardial tissue of neonatal rats after asphyxia,” Chinese Journal of Contemporary Pediatrics, vol. 18, no. 10, pp. 1044–1049, 2016. View at Publisher · View at Google Scholar
  • Shuai Jiang, Dongjin Wang, Shouyin Di, Yang Yang, Wei Yi, Yue Li, Zhiqiang Ma, Chongxi Fan, Wei Hu, and Yang Sun, “A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection,” Progress in Lipid Research, vol. 64, pp. 170–177, 2016. View at Publisher · View at Google Scholar
  • Bilgehan Karadaǧ, “Obesity, leptin, and thrombosis: Focus on clopidogrel resistance,” Turk Kardiyoloji Dernegi Arsivi, vol. 44, no. 7, pp. 543–544, 2016. View at Publisher · View at Google Scholar
  • Takaki Hiwasa, Xiao-Meng Zhang, Risa Kimura, Mikiko Ohno, Po-Min Chen, Eiichiro Nishi, Koh Ono, Takeshi Kimura, Ikuo Kamitsukasa, Takeshi Wada, Akiyo Aotsuka, Seiichiro Mine, Hirotaka Takizawa, Koichi Kashiwado, Minoru Takemoto, Kazuki Kobayashi, Harukiyo Kawamura, Ryoichi Ishibashi, Koutaro Yokote, Rika Nakamura, Go Tomiyoshi, Natsuko Shinmen, and Hideyuki Kuroda, “Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus,” Journal of Circulating Biomarkers, vol. 5, pp. 8, 2016. View at Publisher · View at Google Scholar
  • Edward Milbank, M. Carmen Martinez, and Ramaroson Andriantsitohaina, “Extracellular vesicles: Pharmacological modulators of the peripheral and central signals governing obesity,” Pharmacology & Therapeutics, vol. 157, pp. 65–83, 2016. View at Publisher · View at Google Scholar
  • Chong-Xia Liu, Lin Zhao, Yan-Zheng Tan, Zheng-Bin Zhang, Yang Sun, and Xiao-Ming Wang, “Protective effect of adiponectin on bone marrow mesenchymal stem cell injury caused under fluid shear stress,” Medical Journal of Chinese People's Liberation Army, vol. 41, no. 10, pp. 798–802, 2016. View at Publisher · View at Google Scholar
  • Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Hsu-Lung Jen, Jaw-Wen Chen, and Shing-Jong Lin, “Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-B and Adiponectin,” Mediators of Inflammation, vol. 2016, 2016. View at Publisher · View at Google Scholar
  • Vasyuk, Trofimenko, Yushchuk, Shupenina, Sadulaeva, Ivanova, and Nesterova, “Obesity in metabolic syndrome, as well as kidney dysfunction,” Terapevticheskii Arkhiv, vol. 88, no. 10, pp. 93–98, 2016. View at Publisher · View at Google Scholar
  • Krithika Srikanthan, Andrew Feyh, Haresh Visweshwar, Joseph I. Shapiro, and Komal Sodhi, “Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population,” International Journal Of Medical Sciences, vol. 13, no. 1, pp. 25–38, 2016. View at Publisher · View at Google Scholar
  • Franca Fabiana Kirchberg, Stephanie Brandt, Anja Moß, Wolfgang Peissner, Wolfgang Koenig, Dietrich Rothenbacher, Hermann Brenner, Berthold Koletzko, Christian Hellmuth, and Martin Wabitsch, “Metabolomics reveals an entanglement of fasting leptin concentrations with fatty acid oxidation and gluconeogenesis in healthy children,” Plos One, vol. 12, no. 8, pp. e0183185, 2017. View at Publisher · View at Google Scholar
  • Sonja Fonfara, Sarah Kitz, Udo Hetzel, and Anja Kipar, “Myocardial leptin transcription in feline hypertrophic cardiomyopathy,” Research in Veterinary Science, vol. 112, pp. 105–108, 2017. View at Publisher · View at Google Scholar
  • Pei-Wei Tseng, Du-An Wu, Jia-Sian Hou, and Bang-Gee Hsu, “Leptin is an independent marker of metabolic syndrome in elderly adults with type 2 diabetes,” Tzu Chi Medical Journal, vol. 29, no. 2, pp. 109–114, 2017. View at Publisher · View at Google Scholar
  • Perrine Goguet-Rubio, Joseph I. Shapiro, Komal Sodhi, Rebecca L. Klug, Dana L. Sharma, Krithika Srikanthan, Nitin Puri, Vishal H Lakhani, Alexandra Nichols, Kathleen M. O’Hanlon, and Nader G. Abraham, “Existence of a strong correlation of biomarkers and mirna in females with metabolic syndrome and obesity in a population of West Virginia,” International Journal of Medical Sciences, vol. 14, no. 6, pp. 543–553, 2017. View at Publisher · View at Google Scholar
  • D. Taussky, M. Barkati, S. Campeau, K. Zerouali, A. Nadiri, F. Saad, and G. Delouya, “Changes in periprostatic adipose tissue induced by 5α-reductase inhibitors,” Andrology, 2017. View at Publisher · View at Google Scholar
  • Andrea D. van Dam, Mariëtte R. Boon, Jimmy F.P. Berbée, Patrick C.N. Rensen, and Vanessa van Harmelen, “Targeting white, brown and perivascular adipose tissue in atherosclerosis development,” European Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Veli-Pekka Puurunen, Antti Kiviniemi, Samuli Lepojärvi, Olli-Pekka Piira, Pirjo Hedberg, Juhani Junttila, Olavi Ukkola, and Heikki Huikuri, “Leptin predicts short-term major adverse cardiac events in patients with coronary artery disease,” Annals of Medicine, pp. 1–7, 2017. View at Publisher · View at Google Scholar
  • Ulrika Ljung Faxén, Camilla Hage, Anna Andreasson, Erwan Donal, Jean-Claude Daubert, Cecilia Linde, Kerstin Brismar, and Lars H Lund, “HFpEF and HFrEF exhibit different phenotypes as assessed by leptin and adiponectin,” International Journal of Cardiology, vol. 228, pp. 709–716, 2017. View at Publisher · View at Google Scholar
  • Amanda T. Cao, Martina Mackova, Daniel Kerage, David N. Brindley, and Denise G. Hemmings, “Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3,” Experimental Gerontology, vol. 99, pp. 87–97, 2017. View at Publisher · View at Google Scholar
  • Xiaotong Sun, Jing Wei, Yawei Tang, Bing Wang, Yan Zhang, Lei Shi, Jianping Guo, Fanlei Hu, and Xia Li, “Leptin-induced migration and angiogenesis in rheumatoid arthritis is mediated by reactive oxygen species,” FEBS Open Bio, 2017. View at Publisher · View at Google Scholar
  • Pan Zhou, Yang Zhao, Pan Zhang, Yan Li, Taotao Gui, Jun Wang, Chao Jin, Lianqiang Che, Jian Li, Yan Lin, Shengyu Xu, Bin Feng, Zhengfeng Fang, and De Wu, “Microbial Mechanistic Insight into the Role of Inulin in Improving Maternal Health in a Pregnant Sow Model,” Frontiers in Microbiology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Maria Cybularz, Heike Langbein, Birgit Zatschler, Coy Brunssen, Andreas Deussen, Klaus Matschke, and Henning Morawietz, “Endothelial function and gene expression in perivascular adipose tissue from internal mammary arteries of obese patients with coronary artery disease,” Atherosclerosis Supplements, vol. 30, pp. 149–158, 2017. View at Publisher · View at Google Scholar
  • Gómez-Romero, Alarcón-Sotelo, Rodríguez-Weber, and Díaz-Greene, “Adiponectin as therapeutic target,” Medicina Interna de Mexico, vol. 33, no. 6, pp. 770–777, 2017. View at Publisher · View at Google Scholar
  • Sajjad Muhammad, Shafqat R. Chaudhry, Thomas L. Yearwood, Joachim K. Krauss, and Thomas M. Kinfe, “Changes of Metabolic Disorders Associated Peripheral Cytokine/Adipokine Traffic in Non-Obese Chronic Back Patients Responsive to Burst Spinal Cord Stimulation,” Neuromodulation: Technology at the Neural Interface, 2017. View at Publisher · View at Google Scholar
  • Juan Gabriel Juárez-Rojas, Rosalinda Posadas-Sánchez, María del Rocío Martínez-Alvarado, Margarita Torres-Tamayo, Esteban Jorge-Galarza, Erika Yamel Mancilla-Valenzuela, Carlos Posadas-Romero, Guillermo Celestino Cardoso-Saldaña, María del Carmen González-Salazar, Gilberto Vargas-Alarcón, and Aida Xochitl Medina-Urrutia, “Association of Adiponectin with Subclinical Atherosclerosis in a Mexican-Mestizo Population,” Archives of Medical Research, vol. 48, no. 1, pp. 73–78, 2017. View at Publisher · View at Google Scholar
  • Shingo Hosoo, Masahiro Koyama, Akira Watanabe, Ryuya Ishida, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Keiji Wada, Yukihito Higashi, and Kozo Nakamura, “Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet,” Hypertension Research, 2017. View at Publisher · View at Google Scholar
  • Katja Rietdorf, and Hilary MacQueen, “Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?,” British Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Anna Szczepańska-Szerej, Jacek Kurzepa, Aneta Grabarska, Joanna Bielewicz, Ewa Wlizło-Dyś, and Konrad Rejdak, “ Correlation between CH 2 DS 2 -VASc Score and Serum Leptin Levels in Cardioembolic Stroke Patients: The Impact of Metabolic Syndrome ,” International Journal of Endocrinology, vol. 2017, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Chunhua Yin, Lumei Kang, Cong Lai, Jing Zhou, Bin Shi, Lei Zhang, and Hongping Chen, “Effects of 17β-estradiol on leptin signaling in anterior pituitary of ovariectomized rats,” Experimental Animals, vol. 66, no. 2, pp. 159–166, 2017. View at Publisher · View at Google Scholar
  • Renata Stawerska, Joanna Smyczyńska, Maciej Hilczer, and Andrzej Lewiński, “Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations,” International Journal of Endocrinology, vol. 2017, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Edna Berzabá-Evoli, Cecilia Zazueta, Jarumi Hishel Cruz Hernández, Nancy Patricia Gómez-Crisóstomo, Isela Esther Juárez-Rojop, Erick Natividad De la Cruz-Hernández, and Eduardo Martínez-Abundis, “Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects,” International Journal of Endocrinology, vol. 2018, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Martin A. Alpert, Kamalesh Karthikeyan, Obai Abdullah, and Rugheed Ghadban, “Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications,” Progress in Cardiovascular Diseases, 2018. View at Publisher · View at Google Scholar
  • Beatrice von Jeinsen, Meghan I. Short, Vanessa Xanthakis, Herman Carneiro, Susan Cheng, Gary F. Mitchell, and Ramachandran S. Vasan, “Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort,” Journal of the American Heart Association, vol. 7, no. 13, 2018. View at Publisher · View at Google Scholar
  • Rodrigo Modolo, Heno Ferreira Lopes, Ana Paula de Faria, Arthur Santa Catharina, Alessandra Mileni Versuti Ritter, Andréa Rodrigues Sabbatini, and Heitor Moreno Junior, “Metabolic syndrome-related features in controlled and resistant hypertensive subjects,” Arquivos Brasileiros de Cardiologia, vol. 110, no. 6, pp. 514–521, 2018. View at Publisher · View at Google Scholar
  • Wanli Lu, Sheng Zhou, Long Xue, Bingyang Dai, Liang Qiao, Dongyang Chen, Zhihong Xu, Yao Yao, Huajian Teng, and Qing Jiang, “High preoperative serum leptin level is an independent risk factor for deep vein thrombosis after total knee arthroplasty in osteoarthritis patients,” Medicine, vol. 97, no. 21, pp. e10884, 2018. View at Publisher · View at Google Scholar
  • Jia-Sian Hou, Chih-Hsien Wang, Yu-Hsien Lai, Yu-Li Lin, Chiu-Huang Kuo, Yi-Maun Subeq, and Bang-Gee Hsu, “Negative Correlation of Serum Adiponectin Levels With Carotid–Femoral Pulse Wave Velocity in Patients Treated With Hemodialysis,” Biological Research For Nursing, pp. 109980041876888, 2018. View at Publisher · View at Google Scholar
  • Zheng Gu, Canlin Sun, and Dong Xiang, “Postoperative adverse cardiovascular events associated with leptin and adverse age after elective major non-cardiac surgery: An asian single-center study,” Medical Science Monitor, vol. 24, pp. 2119–2125, 2018. View at Publisher · View at Google Scholar
  • Tara Rendo-Urteaga, Marcela González-Gross, Marika Ferrari, Luis A. Moreno, Francisco Leonardo Torres-Leal, Michael Sjöström, Dénes Molnár, Ascensión Marcos, Heráclito B. Carvalho, Augusto César Ferreira De Moraes, Yannis Manios, Frederic Gottand, Anthony Kafatos, Kurt Widhalm, and Stefaan De Henauw, “Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: The HELENA Study,” Journal of Pediatric Endocrinology and Metabolism, vol. 31, no. 11, pp. 1221–1229, 2018. View at Publisher · View at Google Scholar
  • Maryam Vaezi, Parichehreh Yaghmaei, Nasim Hayati-Roodbari, Shiva Irani, and Azadeh Ebrahim-Habibi, “Citral effect in male NMRI mice nonalcoholic steatosis model: assessing biochemical and histological parameters and PPARα gene expression,” Brazilian Journal of Pharmaceutical Sciences, vol. 54, no. 3, 2018. View at Publisher · View at Google Scholar
  • Amitabha Ray, “Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies,” World Journal of Clinical Cases, vol. 6, no. 12, pp. 483–492, 2018. View at Publisher · View at Google Scholar
  • Pawel Szulc, Ez Zoubir Amri, Annie Varennes, Patricia Panaia-Ferrari, Eric Fontas, Joëlle Goudable, Roland Chapurlat, and Véronique Breuil, “Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men ― The Prospective MINOS Study ―,” Circulation Journal, 2018. View at Publisher · View at Google Scholar
  • Michael R Buckley, Paul D Terry, Stacy S Kirkpatrick, Joshua D Arnold, Michael M McNally, Oscar H Grandas, Michael B Freeman, Mitchell H Goldman, Jay Whelan, and Deidra JH Mountain, “Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention,” Nutrition Research, vol. 68, pp. 34–44, 2019. View at Publisher · View at Google Scholar
  • María Dolores Cañete, Rosario Valle‐Martos, Rosario Martos, Ramón Cañete, Miguel Valle, and Luis Jiménez‐Reina, “Effects of growth hormone therapy on metabolic parameters, adipokine and endothelial dysfunction in prepuberal children,” Acta Paediatrica, 2019. View at Publisher · View at Google Scholar
  • Esther Ngozi Adejumo, Adedeji Olusola Adejumo, Seyi Samson Enitan, Ayodele Oloruntoba Ekun, Alfred Azenabor, Olayimika Kehinde Adebola, and Omobolanle Abioye Ogundahunsi, “Leptin: Adiponectin ratio discriminated the risk of metabolic syndrome better than adiponectin and leptin in southwest Nigeria,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2019. View at Publisher · View at Google Scholar
  • Ignatios Ikonomidis, Victor Aboyans, Jacque Blacher, Marianne Brodmann, Dirk L. Brutsaert, Julio A. Chirinos, Marco De Carlo, Victoria Delgado, Patrizio Lancelotti, John Lekakis, Dania Mohty, Petros Nihoyannopoulos, John Parissis, Damiano Rizzoni, Frank Ruschitzka, Petar Seferovic, Eugenio Stabile, Dimitrios Tousoulis, Dragos Vinereanu, Charalambos Vlachopoulos, Dimitrios Vlastos, Panagiotis Xaplanteris, Reuven Zimlichman, and Marco Metra, “The role of ventricular-arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseas,” European Journal of Heart Failure, 2019. View at Publisher · View at Google Scholar
  • Gema Frühbeck, Victoria Catalán, Amaia Rodríguez, Beatriz Ramírez, Sara Becerril, Javier Salvador, Inmaculada Colina, and Javier Gómez-Ambrosi, “Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation,” Nutrients, vol. 11, no. 2, pp. 454, 2019. View at Publisher · View at Google Scholar
  • Marina Hovakimyan, Venakta Ajay Narendra Talabattula, Claudia Cozma, Christian Beetz, Arndt Rolfs, and Deborah Elstein, “Plasma adiponectin is a potential biomarker for organ involvement in male Fabry disease patients,” Blood Cells, Molecules, and Diseases, pp. 102379, 2019. View at Publisher · View at Google Scholar
  • Deborah Amos, Carla Cook, and Nalini Santanam, “Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019. View at Publisher · View at Google Scholar
  • Rui Hao, Guoying Su, Xiaolin Sun, Xiangran Kong, Cuiying Zhu, and Guohai Su, “Adiponectin attenuates lipopolysaccharide-induced cell injury of H9c2 cells by regulating AMPK pathway,” Acta Biochimica et Biophysica Sinica, 2019. View at Publisher · View at Google Scholar
  • N. M. Bubalo, G. M. Balan, P. G. Zhminko, M. G. Prodanchuk, O. P. Kravchuk, I. O. Rashkivska, T. V. Usenko, V. O. Bubalo, Y. V. Kolyanchuk, S. D. Kolesnyk, and G. I. Petroshenko, “Leptin As A Biomarker Of Metabolic Disorders And Obesity In Patients With Acute Herbicide Poisoning Based On 2,4-Dichlorophenoxyacetic Acid,” Bulletin of Problems Biology and Medicine, vol. 3, no. 152, pp. 84, 2019. View at Publisher · View at Google Scholar