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International Journal of Endocrinology
Volume 2015 (2015), Article ID 564934, 15 pages
Review Article

Osteoprotegerin in Cardiometabolic Disorders

1Department of Clinical Chemistry, Clínica Universidad de Navarra, Avenida Pío XII 36, 31008 Pamplona, Spain
2Department of Cardiovascular Science, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK

Received 3 December 2014; Revised 20 April 2015; Accepted 20 April 2015

Academic Editor: Giorgio Iervasi

Copyright © 2015 C. Pérez de Ciriza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for CVD. This review focuses on the relationship between circulating OPG and different endocrine cardiometabolic alterations such as type 1 and 2 diabetes. The association of OPG with diabetic complications (neuropathy, nephropathy, or retinopathy) as well as with atherosclerosis, coronary artery calcification, morbidity, and mortality is pointed out. Moreover, OPG modulation by different treatments is also established. Besides, other associated diseases such as obesity, hypertension, and metabolic syndrome, which are known cardiovascular risk factors, are also considered.