International Journal of Endocrinology / 2015 / Article / Tab 3

Review Article

Osteoprotegerin in Cardiometabolic Disorders

Table 3

Studies assessing the association between osteoprotegerin and diabetes mellitus type 2.

Author, DatePopulationFindings

O’Sullivan et al., 2010 [42]62 type 2 DM
58 healthy subjects (age, gender, BMI)
OPG is significantly increased in type 2 DM
Altinova et al., 2011 [46]166 type 2 DMOPG levels are higher in poorly controlled DM
Yaturu et al., 2008 [41]50 type 2 DM
59 subjects without DM
OPG is elevated in type 2 DM and correlated with insulin resistance. Cross-sectional study
Knudsen et al., 2003 [48]80 subjects divided in four groups according to glucose toleranceOPG is increased in patients with microvascular complications
Chang et al., 2011 [43]179 type 2 DMOPG is associated with diabetic nephropathy
Xiang et al., 2007 [29]154 newly diagnosed type 2 DM
96 healthy controls
Plasma OPG levels are associated with urinary albumin excretion
Nybo et al., 2010 [34]200 type 1 DM
305 type 2 DM
OPG is increased in patients with peripheral neuropathy
Yu et al., 2015 [49]254 diabetic patients (100 without retinopathy, 154 with retinopathy), 62 controlsOPG is associated with retinopathy. Patients with retinopathy exhibit increased vitreous and serum OPG
Terekeci et al., 2009 [44]42 type 2 DM
24 healthy controls
OPG correlated with diabetic neuropathy
Tavintharan et al., 2014 [47]1,220 type 2 DMHigher OPG levels associated with microvascular complications (nephropathy, neuropathy and retinopathy)
Ishiyama et al., 2009 [50]168 type 2 DM
40 non-diabetic subjects
Diabetic patients had higher IMT and OPG was an independent determinant of IMT
Moreno et al., 2013 [51]68 males (43 with type 2 DM and 25 subjects without diabetes)Serum OPG associated with increased risk of abnormal IMT, carotid plaque, aortic calcification and peripheral disease
Gaudio et al., 2014 [39]40 type 2 DM postmenopausal women
40 healthy controls
OPG associated with IMT
Singh et al., 2012 [54]58 type 2 DMOPG was an independent predictor of baseline vascular calcification and progression
Anand et al., 2006 [55]510 type 2 DMOPG is elevated in patients with CAC
Anand et al., 2007 [56]398 type 2 DMOPG associated with elevated CAC
Bourron et al., 2014 [57]198 type 2 DMLnOPG associated with calcification score. Cross-sectional study
Avignon et al., 2007 [37]645 diabetic patients with one additional risk factorOPG associated with the presence of silent myocardial ischemia
Guzel et al., 2013 [40]45 type 2 DM
33 healthy controls
OPG associated with the presence and severity of silent myocardial ischemia
Reinhard et al., 2011 [58]200 asymptomatic DM patients without known cardiac diseaseOPG independently associated with asymptomatic coronary artery disease
Avignon et al., 2005 [59]162 asymptomatic type 2 DMOPG independently associated with asymptomatic coronary artery disease
Poulsen et al., 2011 [60]305 type 2 DM without known cardiovascular diseaseIncreased plasma OPG associated with carotid and peripheral arterial disease. No association with myocardial ischemia
Blázquez-Medela et al., 2012 [38]52 type 2 patients
54 healthy controls
Higher OPG levels were observed in patients with higher probability of 10-year cardiovascular risk
Reinhard et al., 2010 [61]238 type 2 DMElevated plasma OPG was a strong predictor of all-cause mortality. Follow-up 16.8 years. Prospective observational study

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