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International Journal of Endocrinology
Volume 2015, Article ID 565760, 5 pages
http://dx.doi.org/10.1155/2015/565760
Review Article

Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization

Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, China

Received 24 August 2015; Accepted 4 November 2015

Academic Editor: Darío A. Castroviejo

Copyright © 2015 Yi Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity is now recognized as a low-grade, chronic inflammatory disease that is linked to a myriad of disorders including cardiovascular diseases, type 2 diabetes, and liver diseases. Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue. In this review, we focused on the role of eosinophils in regulating metabolic homeostasis and obesity.