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International Journal of Endocrinology
Volume 2015 (2015), Article ID 576576, 8 pages
http://dx.doi.org/10.1155/2015/576576
Research Article

Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules

Chiara Dobrinja,1 Stella Bernardi,2,3 Bruno Fabris,2,3 Rita Eramo,1 Petra Makovac,1,3 Gabriele Bazzocchi,4 Lanfranco Piscopello,5 Enrica Barro,2,3 Nicolò de Manzini,1,3 Deborah Bonazza,3,6 Maurizio Pinamonti,3,6 Fabrizio Zanconati,3,6 and Fulvio Stacul4

1UCO Chirurgia Generale, Cattinara Teaching Hospital, Strada di Fiume, 34100 Trieste, Italy
2SS Endocrinologia (UCO Medicina Clinica), Cattinara Teaching Hospital, Strada di Fiume, 34100 Trieste, Italy
3Department of Medical, Surgical, and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34100 Trieste, Italy
4SC Radiologia, Maggiore Hospital, Piazza dell’Ospitale, 34100 Trieste, Italy
5SS Endocrinologia (III Medica), Maggiore Hospital, Piazza dell’Ospitale, 34100 Trieste, Italy
6UCO Anatomia e Istologia Patologica, Cattinara Teaching Hospital, Strada di Fiume, 34100 Trieste, Italy

Received 10 March 2015; Revised 14 May 2015; Accepted 1 July 2015

Academic Editor: Jack R. Wall

Copyright © 2015 Chiara Dobrinja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. H. Tan and H. Gharib, “Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging,” Annals of Internal Medicine, vol. 126, no. 3, pp. 226–231, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. D. S. Cooper, G. M. Doherty, B. R. Haugen et al., “Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid, vol. 19, no. 11, pp. 1167–1214, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Gharib, L. Hegedüs, C. M. Pacella, J. H. Baek, and E. Papini, “Nonsurgical, image-guided, minimally invasive therapy for thyroid nodules,” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 10, pp. 3949–3957, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. H. K. Lim, J. H. Lee, E. J. Ha, J. Y. Sung, J. K. Kim, and J. H. Baek, “Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients,” European Radiology, vol. 23, no. 4, pp. 1044–1049, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. J. H. Baek, J. H. Lee, J. Y. Sung et al., “Complications encountered in the treatment of benign thyroid nodules with us-guided radiofrequency ablation: a multicenter study,” Radiology, vol. 262, no. 1, pp. 335–342, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. H. Lee, Y. S. Kim, D. Lee, H. Choi, H. Yoo, and J. H. Baek, “Radiofrequency ablation (RFA) of benign thyroid nodules in patients with incompletely resolved clinical problems after ethanol ablation (EA),” World Journal of Surgery, vol. 34, no. 7, pp. 1488–1493, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Faggiano, V. Ramundo, A. P. Assanti et al., “Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 12, pp. 4439–4445, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Bernardi, C. Dobrinja, B. Fabris et al., “Radiofrequency ablation compared to surgery for the treatment of benign thyroid nodules,” International Journal of Endocrinology, vol. 2014, Article ID 934595, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Crippa and L. Mazzucchelli, “The Bethesda system for reporting thyroid fine-needle aspiration specimens,” American Journal of Clinical Pathology, vol. 134, no. 2, pp. 343–344, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Perros, K. Boelaert, S. Colley et al., “Guidelines for the management of thyroid cancer,” Clinical Endocrinology, vol. 81, no. s1, pp. 1–122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. E. S. Cibas and S. Z. Ali, “The Bethesda system for reporting thyroid cytopathology,” American Journal of Clinical Pathology, vol. 132, no. 5, pp. 658–665, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. D. G. Na, J. H. Lee, S. L. Jung et al., “Radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: consensus statement and recommendations,” Korean Journal of Radiology, vol. 13, no. 2, pp. 117–125, 2012. View at Google Scholar · View at Scopus
  13. C. A. Macias, D. Arumugam, R. L. Arlow et al., “A risk model to determine surgical treatment in patients with thyroid nodules with indeterminate cytology,” Annals of Surgical Oncology, vol. 22, no. 5, pp. 1527–1532, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Dobrinja, G. Trevisan, L. Piscopello, M. Fava, and G. Liguori, “Comparison between thyroidectomy and hemithyroidectomy in treatment of single thyroid nodules identified as indeterminate follicular lesions by fine-needle aspiration cytology,” Annali Italiani di Chirurgia, vol. 81, no. 6, pp. 403–410, 2010. View at Google Scholar · View at Scopus
  15. J. H. Baek, J. H. Lee, R. Valcavi, C. M. Pacella, H. Rhim, and D. G. Na, “Thermal ablation for benign thyroid nodules: radiofrequency and laser,” Korean Journal of Radiology, vol. 12, no. 5, pp. 525–540, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Cochand-Priollet, H. Dahan, M. Laloi-Michelin et al., “Immunocytochemistry with cytokeratin 19 and anti-Human Mesothelial Cell Antibody (HBME1) increases the diagnostic accuracy of thyroid fine-needle aspirations: preliminary report of 150 liquid-based fine-needle aspirations with histological control,” Thyroid, vol. 21, no. 10, pp. 1067–1073, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Fadda, E. D. Rossi, M. Raffaelli et al., “Follicular thyroid neoplasms can be classified as low- and high-risk according to HBME-1 and Galectin-3 expression on liquid-based fine-needle cytology,” European Journal of Endocrinology, vol. 165, no. 3, pp. 447–453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Kuma, F. Matsuzuka, A. Kobayashi et al., “Outcome of long standing solitary thyroid nodules,” World Journal of Surgery, vol. 16, no. 4, pp. 583–588, 1992. View at Publisher · View at Google Scholar · View at Scopus
  19. C.-C. C. Wang, L. Friedman, G. C. Kennedy et al., “A large multicenter correlation study of thyroid nodule cytopathology and histopathology,” Thyroid, vol. 21, no. 3, pp. 243–251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Kim, W. S. Yoo, Y. J. Park et al., “Efficacy and safety of radiofrequency ablation for treatment of locally recurrent thyroid cancers smaller than 2 cm,” Radiology, 2015. View at Publisher · View at Google Scholar
  21. S. J. Lee, S. L. Jung, B. S. Kim et al., “Radiofrequency ablation to treat loco-regional recurrence of well-differentiated thyroid carcinoma,” Korean Journal of Radiology, vol. 15, no. 6, pp. 817–826, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. Monchik, G. Donatini, J. Iannuccilli, and D. E. Dupuy, “Radiofrequency ablation and percutaneous ethanol injection treatment for recurrent local and distant well-differentiated thyroid carcinoma,” Annals of Surgery, vol. 244, no. 2, pp. 296–304, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. T. C. Brown, C. C. Juhlin, J. M. Healy, M. L. Prasad, R. Korah, and T. Carling, “Frequent silencing of RASSF1A via promoter methylation in follicular thyroid hyperplasia: a potential early epigenetic susceptibility event in thyroid carcinogenesis,” JAMA Surgery, vol. 149, no. 11, pp. 1146–1152, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. K. W. Park, J. H. Shin, B.-K. Han, E. Y. Ko, and J. H. Chung, “Inoperable symptomatic recurrent thyroid cancers: preliminary result of radiofrequency ablation,” Annals of Surgical Oncology, vol. 18, no. 9, pp. 2564–2568, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Koda, Y. Murawaki, Y. Hirooka et al., “Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: an analysis of 16 346 treated nodules in 13 283 patients,” Hepatology Research, vol. 42, no. 11, pp. 1058–1064, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Ruzzenente, G. D. Manzoni, M. Molfetta et al., “Rapid progression of hepatocellular carcinoma after radiofrequency ablation,” World Journal of Gastroenterology, vol. 10, no. 8, pp. 1137–1140, 2004. View at Google Scholar · View at Scopus
  27. S. Ke, X.-M. Ding, J. Kong et al., “Low temperature of radiofrequency ablation at the target sites can facilitate rapid progression of residual hepatic VX2 carcinoma,” Journal of Translational Medicine, vol. 8, article 73, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Kong, J. Kong, B. Pan et al., “Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA,” PLoS ONE, vol. 7, no. 5, Article ID e37266, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Kong, L. Kong, J. Kong et al., “After insufficient radiofrequency ablation, tumor-associated endothelial cells exhibit enhanced angiogenesis and promote invasiveness of residual hepatocellular carcinoma,” Journal of Translational Medicine, vol. 10, article 230, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Von Breitenbuch, G. Köhl, M. Guba, E. Geissler, K. W. Jauch, and M. Steinbauer, “Thermoablation of colorectal liver metastases promotes proliferation of residual intrahepatic neoplastic cells,” Surgery, vol. 138, no. 5, pp. 882–887, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Solbiati, T. Livraghi, S. N. Goldberg et al., “Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients,” Radiology, vol. 221, no. 1, pp. 159–166, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Valcavi, S. Piana, G. S. Bortolan, R. Lai, V. Barbieri, and R. Negro, “Ultrasound-guided percutaneous laser ablation of papillary thyroid microcarcinoma: a feasibility study on three cases with pathological and immunohistochemical evaluation,” Thyroid, vol. 23, no. 12, pp. 1578–1582, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Monzani, N. Caraccio, F. Basolo, P. Iacconi, V. LiVolsi, and P. Miccoli, “Surgical and pathological changes after percutaneous ethanol injection therapy of thyroid nodules,” Thyroid, vol. 10, no. 12, pp. 1087–1092, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. M. C. Ries, A. J. Milligan, H. W. Merrick, and R. R. Dobelbower Jr., “Biochemical and cellular effects of radiofrequency intuced interstitial hyperthermia on normal canine liver,” International Journal of Radiation Oncology, Biology, Physics, vol. 14, no. 3, pp. 529–536, 1988. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Blanco, F. Qian, B. Weinberg, N. Stowe, J. M. Anderson, and J. Gao, “Effect of fibrous capsule formation on doxorubicin distribution in radiofrequency ablated rats,” Journal of Biomedical Materials Research Part A, vol. 69, no. 3, pp. 398–406, 2004. View at Google Scholar · View at Scopus