The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males
Table 3
-coefficients between the CYP27A1 rs4674344 SNP and the adiponectin/leptin ratio.
Model 1
Model 2
Model 3
Model 4
-coefficient
value
-coefficient
value
Β-coefficient
value
-coefficient
value
CYP27A1 rs4674344
−0.58
0.0092*
−0.6
0.0077*
−0.57
0.0158*
−0.51
0.0257*
Age
0.03
0.6655
0.03
0.6287
0.05
0.4556
0.06
0.3401
BMI
−0.51
0.0001*
−0.51
0.0002*
−0.51
0.0005*
−0.36
0.0108*
WC
−0.39
<0.0001*
−0.38
<0.0001*
−0.38
<0.0001*
−0.3
<0.0001*
HC
0.23
0.0006*
0.22
0.0010*
0.21
0.0026*
0.14
0.0493*
SBP
−0.08
0.0513
−0.08
0.0399
−0.08
0.0638
−0.05
0.1762
DBP
0.02
0.4605
0.02
0.5053
0.02
0.4651
0.02
0.4403
Exsmoker
−0.54
0.2496
−0.44
0.3763
−0.33
0.4908
Current smoker
0.31
0.4731
0.18
0.6967
0.15
0.729
Ex-betel nut chewer
−0.02
0.9961
−0.21
0.9507
−0.16
0.9597
Current betel nut chewer
−0.05
0.9776
0.22
0.907
0.34
0.853
Exdrinker
−0.28
0.6513
−0.58
0.3906
−0.63
0.3326
Current drinker
0.96
0.3427
1.39
0.2231
1.35
0.2198
DM
−0.17
0.6799
0.21
0.6329
Hypertension
−0.09
0.7559
0.02
0.9296
Dyslipidemia
−0.5
0.0887
−0.14
0.6479
CAD
−0.53
0.2821
−0.34
0.4727
Stroke
−2.27
0.3797
−2.12
0.3933
Fasting glucose
−7.02
0.0414*
CHOL(T)
14.3
0.2066
LDL
−13.04
0.0125*
HDL
4.25
0.5984
TG
−7.73
0.0003*
Model 1 is adjusted for baseline characteristics, including age, BMI (body mass index), WC (waist circumference), HC (hip circumference), SBP (systolic blood pressure), and DBP (diastolic blood pressure); Model 2 is further adjusted for habits, including being exsmoker, current smoker, ex-betel nut chewer, current betel nut chewer, exdrinker, and current drinker; Model 3 is further adjusted for comorbidities, including DM (diabetes mellitus), hypertension, dyslipidemia, CAD (coronary artery disease), and stroke; Model 4 is further adjusted for biochemistry data, including fasting glucose, CHOL(T) ( total cholesterol), LDL (low density lipoprotein), HDL (high density lipoprotein), and TG (triglycerides). Significant difference ().
