The Estimation of First-Phase Insulin Secretion by Using Components of the Metabolic Syndrome in a Chinese Population
Table 2
Demographic data of normal glucose tolerance, prediabetes, and diabetes groups.
Normal glucose tolerance
Prediabetes
Diabetes
51
40
95
Age (y)
42.5 ± 17.22,3
54.4 ± 11.91
53.7 ± 10.31
Body mass index (kg/m2)
26.1 ± 5.9
24.9 ± 3.1
25.1 ± 3.5
Systolic blood pressure (mmHg)
118.1 ± 10.9
121.0 ± 14.7
121.9 ± 14.9
Diastolic blood pressure (mmHg)
74.0 ± 6.8
76.1 ± 8.5
76.4 ± 8.5
Triglyceride (mmol/L)
1.2 ± 0.6
1.4 ± 0.6
1.4 ± 0.6
HDL-C (mmol/L)
1.1 ± 0.3
1.1 ± 0.3
1.1 ± 0.3
Fasting plasma glucose (mmol/L)
4.6 ± 0.52,3
6.4 ± 0.41,3
9.9 ± 2.21,2
Fasting plasma insulin (pmol/L)
49.5 (9.3–81.1)
25.5 (7.5–61.7)
23.0 (14.4–44.3)
First-phase insulin secretion (U/min)
517.5 (183.0–5144.7)2,3
123.6 (35.5–390.7)1
37.8 (11.6–158.3)1
Insulin sensitivity (10−4⋅min−1⋅pmol−1⋅L−1)
0.8 (0.2–3.2)
1.9 (0.6–4.4)
1.4 (0.6–2.9)
Disposition index
893.9 (240.0–2447.1)2,3
54.8 (21.7–894.6)1
40.7 (8.3–182.5)1
Glucose effectiveness (10−2⋅dL⋅min−1⋅kg−1)
0.020 ± 0.0102,3
0.014 ± 0.0081
0.014 ± 0.0101
HOMA-IR
1.7 (0.4–2.7)
1.3 (0.3–3.1)
1.7 (0.8–3.3)
HOMA-
134.0 (27.9–352.4)2,3
29.0 (10.4–72.6)1,3
13.0 (6.2–26.4)1,2
Data are expressed as mean ± SD or median (interquartile range). HDL-C: high-density lipoprotein cholesterol; HOMA-IR and HOMA-: homeostasis model assessment of insulin resistance and -cell function. value < 0.05 when compared with “Normal glucose tolerance” group; value < 0.05 when compared with “Pre-diabetes” group; value < 0.05 when compared with “diabetes” group.