Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D

Figure 1

Effect of insulin on phospholipase D activity in rat tissues slices. (a) [¹⁴C]phosphatidylethanol, (b) [¹⁴C]phosphatidylcholine. Formation of [¹⁴C]phosphatidylethanol and degradation of substratum of phospholipase D, [¹⁴C]phosphatidylcholine in the presence of 300 mM ethanol and 10 nM insulin was determined as described in the Methods. , insulin versus control.

(a)

(b)