The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in Overweight/Obese Subjects with Nondiabetic Fasting Glucose
Table 1
Features of male patients according to tertiles of waist circumference, LAP, and HOMA-IR.
Age (years)a
BMI (kg/m2)a
Waist (cm)a
LAP (cm × mmol/L)b
Glucose (mmol/L)b
Insulin (μU/dL)b
HOMA-IRb
2h-PG (mmol/L)b
Overall ()
45.6 (12.9)
36.7 (6.1)
116.4 (13.2)
85.8 [54.6–120.3]
5.3 (0.7)
16.4 (9.2)
3.9 (2.4)
6.3 [5.6–8.1]
Waist tertiles
I ()
45.3 (13.0)
31.2 (2.7)
102.6 (15.3)
55.2 [41.3–82.7]†
5.1 (0.7)
12.8 (8.5)‡
3.0 (2.4)‡
6.3 [5.6–8.2]
II ()
46.6 (14.2)
35.9 (3.0)
115.3 (3.3)
89.8 [71.0–120.5]
5.5 (0.7)
15.8 (7.0)
3.9 (2.1)
6.3 [5.7–8.6]
III ()
45.0 (12.3)
42.8 (5.0)
130.8 (7.8)
103.3 [76.7–132.1]
5.2 (0.7)
20.3 (10.2)
4.7 (2.4)
6.0 [5.0–7.8]
value*
0.895
<0.001
<0.001
0.002
0.179
0.006
0.017
0.428
LAP tertiles
I ()
46.0 (13.8)
33.0 (4.2)
107.9 (11.3)†
49.9 [40.2–56.1]
5.1 (0.7)
12.2 (7.0)‡
2.8 (1.8)‡
6.0 [4.9–7.0]‡
II ()
47.6 (13.2)
36.5 (4.8)
118.0 (9.3)
86.8 [75.5–96.5]
5.3 (0.7)
16.0 (6.8)
3.9 (2.0)
6.1 [5.7–7.9]
III ()
43.2 (12.1)
41.1 (6.6)
124.0 (13.7)
131.0 [121.0–174.3]
5.3 (0.8)
21.2 (11.4)
5.0 (2.9)
6.4 [5.9–8.6]
value*
0.451
<0.001
<0.001
<0.001
0.525
<0.001
0.003
0.049
HOMA tertiles
I ()
45.8 (13.0)
33.9 (5.4)‡
109.6 (11.3)
54.6 [41.3–89.5]‡
4.8 (0.6)†
7.7 (2.8)
1.6 (0.5)
6.1 [4.9–7.1]
II ()
45.7 (14.7)
36.6 (5.1)
116.7 (13.0)
82.0 [55.1–121.1]
5.4 (0.5)
13.5 (1.9)
3.2 (0.4)
5.7 [4.9–7.2]
III ()
44.6 (11.9)
39.4 (6.7)
121.8 (13.3)
101.3 [69.7–131.5]
5.5 (0.8)
25.8 (27.8)
6.3 (2.2)
6.4 [6.0–8.8]†
value*
0.927
0.003
0.002
0.001
0.002
<0.001
<0.001
0.010
Data are reported as mean (standard deviation)a or median [interquartile range, 25th–75th percentile]b or percentage. Percentages are calculated within groups. BMI, body mass index; LAP, lipid accumulation product; HOMA-IR, homeostasis model assessment of insulin resistance; 2h-PG, 2-hour oral postload glucose. *According to ANOVA or Kruskal-Wallis test. All the groups significantly different () to one another by post hoc comparisons of means. † versus the other groups by post hoc comparisons of means. ‡, 1st tertile versus 3rd tertile by post hoc comparisons of means.
