The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in Overweight/Obese Subjects with Nondiabetic Fasting Glucose
Table 2
Features of female patients according to tertiles of waist circumference, LAP, and HOMA-IR.
Age (years)a
BMI (kg/m2)a
Waist (cm)a
LAP (cm × mmol/L)b
Glucose (mmol/L)b
Insulin (U/dL)b
HOMA-IR b
2h-PG (mmol/L)b
Overall ()
40.1 (12.1)
36.9 (6.2)
104.0 (13.0)
56.9 [40.3–89.1]
5.1 (0.6)
13.4 (7.8)
3.1 (2.0)
6.9 [5.8–8.4]
Waist tertiles
I ()
37.6 (11.7)
31.9 (2.8)
90.8 (4.3)
38.7 [24.6–49.8]†
4.9 (0.6)‡
10.7 (4.5)
2.3 (1.1)‡
5.3 [6.1–7.4]†
II ()
41.4 (11.4)
36.3 (4.1)
102.2 (3.4)
58.6 [46.0–85.3]
5.1 (0.7)
13.1 (6.6)
3.0 (1.7)
7.2 [6.1–8.7]
III ()
41.3 (12.6)
42.6 (5.7)
119.3 (8.1)
90.2 [65.2–124.5]
5.2 (0.6)
16.5 (10.1)†
3.9 (2.5)
7.4 [6.3–8.8]
value*
0.048
<0.001
<0.001
<0.001
0.001
<0.001
<0.001
<0.001
LAP tertiles
I ()
38.3 (11.9)
33.4 (4.5)
94.9 (9.2)
32.2 [24.4–40.3]
4.8 (0.5)
10.4 (5.7)
2.3 (1.4)
6.2 [5.2–7.0]
II ()
39.5 (12.4)
36.7 (4.9)
103.2 (10.1)
59.6 [49.6–68.7]
5.0 (0.6)
13.0 (7.7)
2.9 (1.8)
6.5 [5.7–7.9]
III ()
42.4 (11.5)
40.8 (6.6)
114.1 (11.7)
105.0 [89.9–124.5]
5.3 (0.6)†
16.8 (8.4)
4.0 (2.2)
8.4 [7.3–10.5]†
value*
0.058
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
HOMA tertiles
I ()
40.1 (12.1)
35.0 (5.8)
100.3 (12.7)
44.3 [32.0–66.2]
4.7 (0.5)
6.4 (2.0)
1.3 (0.4)
6.3 [5.2–7.6]
II ()
39.4 (11.7)
36.8 (5.6)
103.3 (11.9)
56.9 [40.4–88.0]
5.0 (0.6)
12.1 (2.1)
2.7 (0.4)
6.9 [5.7–8.4]
III ()
40.7 (12.3)
38.9 (6.4)†
108.4 (13.0)†
83.0 [49.5–116.5]
5.4 (0.6)
21.7 (7.6)
5.2 (1.9)
7.7 [6.3–9.8]†
value*
0.659
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
Data are reported as mean (standard deviation)a or median [interquartile range, 25th–75th percentile]b or percentage. Percentages are calculated within groups. BMI, body mass index; LAP, lipid accumulation product; HOMA-IR, homeostasis model assessment of insulin resistance; 2h-PG, 2-hour oral post load glucose. *According to ANOVA or Kruskal-Wallis test. All the groups significantly different () to one another by post hoc comparisons of means. † versus the other groups by post hoc comparisons of means. ‡, 1st tertile versus 3rd tertile by post hoc comparisons of means.
