The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in Overweight/Obese Subjects with Nondiabetic Fasting Glucose

Table 3

Performance and comparison of insulin-resistance indices and waist circumference in identifying abnormalities in glucose metabolism by 2-hour postload glucose of an oral glucose tolerance test.

		LAP	HOMA-IR	Waist	value^*	value^**
IGT	OR (95% CI)^†	2.37 [1.70–3.30]	1.39 [1.03–1.89]	1.44 [1.06–1.94]	0.006	0.978
	value	<0.001	0.014	0.019
	Cases correctly classified (%)	75.8	76.0	75.8
	AUC (95% CI)	0.70 [0.65–0.75]	0.61 [0.56–0.66]	0.61 [0.56–0.66]
T2-DM	OR (95% CI)^†	3.17 [1.75–5.77]	3.12 [1.72–5.66]	1.33 [0.83–2.15]	0.920	0.024
	value	<0.001	<0.001	0.235
	Cases correctly classified (%)	91.9	91.7	91.9
	AUC (95% CI)	0.77 [0.72–0.81]	0.76 [0.72–0.81]	0.66 [0.61–0.71]
Composite IGT and T2-DM	OR (95% CI)^†	3.12 [2.26–4.31]	1.90 [1.42–2.53]	1.51 [1.14–1.99]	0.007	0.185
	value	<0.001	0.001	0.139
	Cases correctly classified (%)	70.6	69.1	66.3
	AUC (95% CI)	0.76 [0.71–0.80]	0.68 [0.63–0.73]	0.65 [0.59–0.69]

LAP, lipid accumulation product; HOMA-IR, homeostasis model assessment of insulin resistance; OR, odds ratio; AUC, area under the curve; 95% CI, 95% confidence interval; IGT, impaired glucose tolerance; T2-DM, type-2 diabetes mellitus.
^*LAP versus HOMA-IR.
^**Waist circumference versus HOMA-IR.
^†For linear increase over sex-specific tertiles of the distribution according to logistic regression adjusted for age (continuous) and smoking (current versus former smoker/nonsmoker).