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International Journal of Endocrinology
Volume 2015, Article ID 872193, 8 pages
http://dx.doi.org/10.1155/2015/872193
Research Article

Soluble α-Klotho Serum Levels in Chronic Kidney Disease

1Department of Cardiovascular, Respiratory, Nephrology, Geriatric, and Anesthetic Sciences, “Sapienza” University, 5 Piazzale Aldo Moro, 00185 Rome, Italy
2Department of Public Health and Infectious Diseases, Section of Statistics, “Sapienza” University, 5 Piazzale Aldo Moro, 00185 Rome, Italy

Received 8 August 2014; Accepted 17 November 2014

Academic Editor: Andrea Del Fattore

Copyright © 2015 Silverio Rotondi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. S. Mian, “Sequence, structural, functional, and phylogenetic analyses of three glycosidase families,” Blood Cells, Molecules and Diseases, vol. 24, no. 2, pp. 83–100, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Kurosu, Y. Ogawa, M. Miyoshi et al., “Regulation of fibroblast growth factor-23 signaling by Klotho,” The Journal of Biological Chemistry, vol. 281, no. 10, pp. 6120–6123, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. I. Urakawa, Y. Yamazaki, T. Shimada et al., “Klotho converts canonical FGF receptor into a specific receptor for FGF23,” Nature, vol. 444, no. 7120, pp. 770–774, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Liu, W. Tang, J. Zhou et al., “Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D,” Journal of the American Society of Nephrology, vol. 17, no. 5, pp. 1305–1315, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. C.-D. Chen, S. Podvin, E. Gillespie, S. E. Leeman, and C. R. Abraham, “Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 50, pp. 19796–19801, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. M. C. Hu, M. Kuro-O, and O. W. Moe, “Klotho and chronic kidney disease,” Contributions to Nephrology, vol. 180, pp. 47–63, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. C. Hu, M. Kuro-o, and O. W. Moe, “Renal and extrarenal actions of Klotho,” Seminars in Nephrology, vol. 33, no. 2, pp. 118–129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. C. Hu, M. Shi, J. Zhang et al., “Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule,” The FASEB Journal, vol. 24, no. 9, pp. 3438–3450, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. S.-K. Cha, B. Ortega, H. Kurosu, K. P. Rosenblatt, M. Kuro, and C.-L. Huang, “Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 28, pp. 9805–9810, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Kuro-O, “Phosphate and klotho,” Kidney International, vol. 79, no. 121, pp. S20–S23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Aizawa, Y. Saito, T. Nakamura et al., “Downregulation of the klotho gene in the kidney under sustained circulatory stress in rats,” Biochemical and Biophysical Research Communications, vol. 249, no. 3, pp. 865–871, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Yu, M. Deng, J. Zhao, and L. Huang, “Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice,” Biochemical and Biophysical Research Communications, vol. 391, no. 1, pp. 261–266, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Olauson, K. Lindberg, R. Amin et al., “Targeted deletion of klotho in kidney distal tubule disrupts mineral metabolism,” Journal of the American Society of Nephrology, vol. 23, no. 10, pp. 1641–1651, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Cozzolino, P. Ureña-Torres, M. G. Vervloet et al., “Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome?” Nephrology Dialysis Transplantation, vol. 29, no. 10, pp. 1815–1820, 2014. View at Publisher · View at Google Scholar
  15. National Kidney Foundation, “K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification,” American Journal of Kidney Diseases, vol. 39, pp. S1–S266, 2002. View at Google Scholar
  16. M. C. Hu, M. Shi, J. Zhang et al., “Klotho deficiency causes vascular calcification in chronic kidney disease,” Journal of the American Society of Nephrology, vol. 22, no. 1, pp. 124–136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Koh, T. Fujimori, S. Nishiguchi et al., “Severely reduced production of klotho in human chronic renal failure kidney,” Biochemical and Biophysical Research Communications, vol. 280, no. 4, pp. 1015–1020, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Akimoto, T. Kimura, Y. Watanabe et al., “The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein,” Transplantation Proceedings, vol. 45, no. 1, pp. 134–136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. I. Pavik, P. Jaeger, L. Ebner et al., “Secreted Klotho and FGF23 in chronic kidney disease stage 1 to 5: a sequence suggested from a cross-sectional study,” Nephrology Dialysis Transplantation, vol. 28, no. 2, pp. 352–359, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Seiler, M. Wen, H. J. Roth et al., “Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease,” Kidney International, vol. 83, no. 1, pp. 121–128, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Wan, C. Smith, V. Shah et al., “Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease,” Nephrology Dialysis Transplantation, vol. 28, no. 1, pp. 153–161, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Devaraj, B. Syed, A. Chien, and I. Jialal, “Validation of an immunoassay for soluble Klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease,” American Journal of Clinical Pathology, vol. 137, no. 3, pp. 479–485, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. A. C. Heijboer, M. A. Blankenstein, J. Hoenderop, M. H. De Borst, and M. G. Vervloet, “Laboratory aspects of circulating α-Klotho,” Nephrology Dialysis Transplantation, vol. 28, no. 9, pp. 2283–2287, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Sakan, K. Nakatani, O. Asai et al., “Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism,” PLoS ONE, vol. 9, no. 1, Article ID e86301, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. E. A. Imel, M. Peacock, P. Pitukcheewanont et al., “Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, pp. 2055–2061, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Yamazaki, A. Imura, I. Urakawa et al., “Establishment of sandwich ELISA for soluble alpha-Klotho measurement: age-dependent change of soluble alpha-Klotho levels in healthy subjects,” Biochemical and Biophysical Research Communications, vol. 398, no. 3, pp. 513–518, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, and D. Roth, “A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation,” Annals of Internal Medicine, vol. 130, no. 6, pp. 461–470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Yokoyama, A. Imura, I. Ohkido et al., “Serum soluble α-klotho in hemodialysis patients,” Clinical Nephrology, vol. 77, no. 5, pp. 347–351, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Kitagawa, H. Sugiyama, H. Morinaga et al., “A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease,” PLoS ONE, vol. 8, no. 2, Article ID e56695, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Nowak, B. Friedrich, F. Artunc et al., “Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients,” PLoS ONE, vol. 9, no. 7, Article ID e100688, 2014. View at Publisher · View at Google Scholar
  31. T. Akimoto, H. Yoshizawa, Y. Watanabe et al., “Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease,” BMC Nephrology, vol. 13, article 155, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. M.-C. Hu, M. Shi, J. Zhang, H. Quĩones, M. Kuro-O, and O. W. Moe, “Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective,” Kidney International, vol. 78, no. 12, pp. 1240–1251, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Hasegawa, N. Nagano, I. Urakawa et al., “Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease,” Kidney International, vol. 78, no. 10, pp. 975–980, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Lindberg, R. Amin, O. W. Moe et al., “The kidney is the principal organ mediating klotho effects,” Journal of the American Society of Nephrology, vol. 25, pp. 2169–2175, 2014. View at Google Scholar