Research Article
Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children
Table 2
Association of the INSIG2 -102G>A polymorphism with obesity.
| | | Genotype | OR (95% CI) | P value | | | GG (%) | GA (%) | AA (%) | GA + AA (%) |
| | Total | | | | | | | | Nonobese | 1234 (93.2) | 83 (6.3) | 7 (0.5) | 90 (6.8) | | | | Obese | 643 (91.2) | 59 (8.4) | 3 (0.4) | 62 (8.8) | 1.41 (0.998–2.00) | 0.051 | | Severely obese | 427 (89.9) | 45 (9.5) | 3 (0.6) | 48 (10.1) | 1.62 (1.11–2.36) | 0.012 | | Boys | | | | | | | | Nonobese | 691 (94.3) | 40 (5.5) | 2 (0.3) | 42 (5.7) | | | | Obese | 442 (91.3) | 39 (8.1) | 3 (0.6) | 42 (8.7) | 1.57 (0.996–2.46) | 0.052 | | Severely obese | 248 (89.5) | 26 (9.4) | 3 (1.1) | 29 (10.5) | 1.91 (1.15–3.17) | 0.012 | | Girls | | | | | | | | Nonobese | 543 (91.9) | 43 (7.3) | 5 (0.8) | 48 (8.1) | | | | Obese | 201 (91.0) | 20 (9.0) | 0 (0) | 20 (9.0) | 1.23 (0.71–2.16) | 0.461 | | Severely obese | 179 (90.4) | 19 (9.6) | 0 (0) | 19 (9.6) | 1.30 (0.73–2.32) | 0.367 |
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P value of logistic regression under dominant model adjusted for age, age square, and study population.
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