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International Journal of Endocrinology
Volume 2015, Article ID 896758, 11 pages
http://dx.doi.org/10.1155/2015/896758
Clinical Study

Determinants of Vitamin D Levels in Children and Adolescents with Down Syndrome

1Health Sciences Department, Anna Meyer Children’s University Hospital, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy
2Genetics and Molecular Medicine Unit, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, Italy

Received 21 September 2014; Accepted 28 December 2014

Academic Editor: Andre P. Kengne

Copyright © 2015 Stefano Stagi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. E. Weijerman, A. M. van Furth, A. Vonk Noordegraaf, J. P. van Wouwe, C. J. M. Broers, and R. J. B. J. Gemke, “Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: a national study,” The Journal of Pediatrics, vol. 152, no. 1, pp. 15–19, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Hawli, M. Nasrallah, and G. E.-H. Fuleihan, “Endocrine and musculoskeletal abnormalities in patients with Down syndrome,” Nature Reviews Endocrinology, vol. 5, no. 6, pp. 327–334, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. F. K. Wiseman, K. A. Alford, V. L. J. Tybulewicz, and E. M. C. Fisher, “Down syndrome—recent progress and future prospects,” Human Molecular Genetics, vol. 18, no. 1, pp. R75–R83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. M. Reza, H. Rasool, S. Mansour, and H. Abdollah, “Effects of calcium and training on the development of bone density in children with Down syndrome,” Research in Developmental Disabilities, vol. 34, no. 12, pp. 4304–4309, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. Á. Matute-Llorente, A. González-Agüero, A. Gómez-Cabello, G. Vicente-Rodríguez, and J. A. Casajús, “Decreased levels of physical activity in adolescents with down syndrome are related with low bone mineral density: a cross-sectional study,” BMC Endocrine Disorders, vol. 13, article 22, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Wu, “Bone mass and density in preadolescent boys with and without Down syndrome,” Osteoporosis International, vol. 24, no. 11, pp. 2847–2854, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. A. González-Agüero, G. Vicente-Rodríguez, L. A. Moreno, and J. A. Casajús, “Bone mass in male and female children and adolescents with Down syndrome,” Osteoporosis International, vol. 22, no. 7, pp. 2151–2157, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. A. González-Agüero, G. Vicente-Rodríguez, A. Gómez-Cabello, and J. A. Casajús, “Cortical and trabecular bone at the radius and tibia in male and female adolescents with Down syndrome: a peripheral quantitative computed tomography (pQCT) Study,” Osteoporosis International, vol. 24, no. 3, pp. 1035–1044, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Ferry, M. Gavris, C. Tifrea et al., “The bone tissue of children and adolescents with Down syndrome is sensitive to mechanical stress in certain skeletal locations: a 1-year physical training program study,” Research in Developmental Disabilities, vol. 35, no. 9, pp. 2077–2084, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. J. R. Geijer, H. I. Stanish, C. C. Draheim, and D. R. Dengel, “Bone mineral density in adults with down syndrome, intellectual disability, and nondisabled adults,” American Journal on Intellectual and Developmental Disabilities, vol. 119, no. 2, pp. 107–114, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. D. A. Wahl, C. Cooper, P. R. Ebeling et al., “A global representation of vitamin D status in healthy populations,” Archives of Osteoporosis, vol. 7, no. 1-2, pp. 155–172, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Pludowski, W. B. Grant, H. P. Bhattoa et al., “Vitamin D status in central Europe,” International Journal of Endocrinology, vol. 2014, Article ID 589587, 12 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Lips, T. Duong, A. Oleksik et al., “A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial,” The Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 3, pp. 1212–1221, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Stagi, L. Cavalli, F. Bertini et al., “Vitamin D levels in children, adolescents, and young adults with juvenile-onset systemic lupus erythematosus: a cross-sectional study,” Lupus, vol. 23, no. 10, pp. 1059–1065, 2014. View at Google Scholar
  15. S. Stagi, F. Bertini, L. Cavalli, M. Matucci-Cerinic, M. L. Brandi, and F. Falcini, “Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis,” The Journal of Rheumatology, vol. 41, no. 9, pp. 1884–1892, 2014. View at Publisher · View at Google Scholar
  16. S. Mansoor, A. Habib, F. Ghani et al., “Prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults,” Clinical Biochemistry, vol. 43, no. 18, pp. 1431–1435, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. N. M. van Schoor and P. Lips, “Worldwide vitamin D status,” Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 25, no. 4, pp. 671–680, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Lippi, M. Montagnana, and G. Targher, “Vitamin D deficiency among Italian children,” Canadian Medical Association Journal, vol. 177, no. 12, pp. 1529–1530, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Vierucci, M. del Pistoia, M. Fanos et al., “Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a Cross-Sectional Study,” European Journal of Pediatrics, vol. 172, no. 12, pp. 1607–1617, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Stagi, P. Pelosi, M. Strano et al., “Determinants of vitamin D levels in Italian children and adolescents: a longitudinal evaluation of cholecalciferol supplementation versus the improvement of factors influencing 25(OH)D status,” International Journal of Endocrinology, vol. 2014, Article ID 583039, 13 pages, 2014. View at Publisher · View at Google Scholar
  21. S. Christakos and H. F. DeLuca, “Minireview: vitamin D: is there a role in extraskeletal health?” Endocrinology, vol. 152, no. 8, pp. 2930–2936, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Arnson, H. Amital, and Y. Shoenfeld, “Vitamin D and autoimmunity: new aetiological and therapeutic considerations,” Annals of the Rheumatic Diseases, vol. 66, no. 9, pp. 1137–1142, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Visser, D. J. H. Deeg, and P. Lips, “Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 12, pp. 5766–5772, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. A. J. Rovner and K. O. O'Brien, “Hypovitaminosis D among healthy children in the United States: a review of the current evidence,” Archives of Pediatrics and Adolescent Medicine, vol. 162, no. 6, pp. 513–519, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. F. Holick, “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease,” he American Journal of Clinical Nutrition, vol. 80, no. 6, supplement, pp. 1678S–1688S, 2004. View at Google Scholar · View at Scopus
  26. P. Zubillaga, A. Garrido, I. Mugica, J. Ansa, R. Zabalza, and J. I. Emparanza, “Effect of vitamin D and calcium supplementation on bone turnover in institutionalized adults with Down's Syndrome,” European Journal of Clinical Nutrition, vol. 60, no. 5, pp. 605–609, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. C. del Arco, J. A. Riancho, C. Luzuriaga, J. Gonzalez-Macias, and J. Florez, “Vitamin D status in children with Down's syndrome,” Journal of Intellectual Disability Research, vol. 36, no. 3, pp. 251–257, 1992. View at Google Scholar · View at Scopus
  28. M. F. Holick, “Vitamin D status: measurement, interpretation, and clinical application,” Annals of Epidemiology, vol. 19, no. 2, pp. 73–78, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. M. F. Holick, “Resurrection of vitamin D deficiency and rickets,” The Journal of Clinical Investigation, vol. 116, no. 8, pp. 2062–2072, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Berg, The Nutritional Factor: Its Role in National Development, vol. 12, The Brookings Institution, Washington, DC, USA, 1973.
  31. S. Salvini, M. Parpinel, P. Gnagnarella, P. Maisonneuve, and A. Turrini, Dati di Composizione degli Alimenti per Studi Epidemiologici in Italia, Istituto Europeo di Oncologi, Milan, Italy, 1998.
  32. S. Stagi, E. Lapi, E. Gambineri et al., “Bone density and metabolism in subjects with microdeletion of chromosome 22q11 (del22q11),” European Journal of Endocrinology, vol. 163, no. 2, pp. 329–337, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. L. Wagner, F. R. Greer, American Academy of Pediatrics Section on Breastfeeding, and American Academy of Pediatrics Committee on Nutrition, “Prevention of rickets and vitamin D deficiency in infants, children, and adolescents,” Pediatrics, vol. 122, no. 5, pp. 1142–1152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Braegger, C. Campoy, V. Colomb et al., “Vitamin D in the healthy European paediatric population,” Journal of Pediatric Gastroenterology and Nutrition, vol. 56, no. 6, pp. 692–701, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. Å. Myrelid, J. Gustafsson, B. Ollars, and G. Annerén, “Growth charts for Down's syndrome from birth to 18 years of age,” Archives of Disease in Childhood, vol. 87, no. 2, pp. 97–103, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Cacciari, S. Milani, A. Balsamo et al., “Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr),” Journal of Endocrinological Investigation, vol. 29, no. 7, pp. 581–593, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Broyles, P. T. Katzmarzyk, S. R. Srinivasan et al., “The pediatric obesity epidemic continues unabated in Bogalusa, Louisiana,” Pediatrics, vol. 125, no. 5, pp. 900–905, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Stagi, L. Galli, C. Cecchi et al., “Final height in patients perinatally infected with the human immunodeficiency virus,” Hormone Research in Paediatrics, vol. 74, no. 3, pp. 165–171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. W. A. Marshall and J. M. Tanner, “Variations in pattern of pubertal changes in girls,” Archives of Disease in Childhood, vol. 44, no. 235, pp. 291–303, 1969. View at Publisher · View at Google Scholar · View at Scopus
  40. W. A. Marshall and J. M. Tanner, “Variations in the pattern of pubertal changes in boys,” Archives of Disease in Childhood, vol. 45, no. 239, pp. 13–23, 1970. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Stagi, E. Lapi, C. Cecchi et al., “Williams-Beuren syndrome is a genetic disorder associated with impaired glucose tolerance and diabetes in childhood and adolescence: new insights from a longitudinal study,” Hormone Research in Paediatrics, vol. 82, no. 1, pp. 38–43, 2014. View at Publisher · View at Google Scholar
  42. A. Huotari and K. H. Herzig, “Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency,” International Journal of Circumpolar Health, vol. 67, no. 2-3, pp. 164–178, 2008. View at Google Scholar · View at Scopus
  43. J. El Hayek, G. Egeland, and H. Weiler, “Vitamin D status of Inuit preschoolers reflects season and vitamin D intake,” The Journal of Nutrition, vol. 140, no. 10, pp. 1839–1845, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. N. F. Carvalho, R. D. Kenney, P. H. Carrington, and D. E. Hall, “Severe nutritional deficiencies in toddlers resulting from health food milk alternatives,” Pediatrics, vol. 107, no. 4, article E46, 2001. View at Google Scholar · View at Scopus
  45. F. P. Pellegrini, M. Marinoni, V. Frangione et al., “Down syndrome, autoimmunity and T regulatory cells,” Clinical and Experimental Immunology, vol. 169, no. 3, pp. 238–243, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. D. V. Edidin, L. L. Levitsky, W. Schey, N. Dumbovic, and A. Campos, “Resurgence of nutritional rickets associated with breast-feeding and special dietary practices,” Pediatrics, vol. 65, no. 2, pp. 232–235, 1980. View at Google Scholar · View at Scopus
  47. C. M. Gordon, K. C. DePeter, H. A. Feldman, E. Grace, and S. J. Emans, “Prevalence of vitamin D deficiency among healthy adolescents,” Archives of Pediatrics and Adolescent Medicine, vol. 158, no. 6, pp. 531–537, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Wortsman, L. Y. Matsuoka, T. C. Chen, Z. Lu, and M. F. Holick, “Decreased bioavailability of vitamin D in obesity,” The American Journal of Clinical Nutrition, vol. 72, no. 3, pp. 690–693, 2000. View at Google Scholar · View at Scopus
  49. K. Fiscella and P. Franks, “Vitamin D, race, and cardiovascular mortality: findings from a national US sample,” Annals of Family Medicine, vol. 8, no. 1, pp. 11–18, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. S. Pilz, W. März, B. Wellnitz et al., “Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 10, pp. 3927–3935, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Pilz, H. Dobnig, J. E. Fischer et al., “Low vitamin D levels predict stroke in patients referred to coronary angiography,” Stroke, vol. 39, no. 9, pp. 2611–2613, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. J. P. Forman, E. Giovannucci, M. D. Holmes et al., “Plasma 25-hydroxyvitamin D levels and risk of incident hypertension,” Hypertension, vol. 49, no. 5, pp. 1063–1069, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. L. G. Danescu, S. Levy, and J. Levy, “Vitamin D and diabetes mellitus,” Endocrine, vol. 35, no. 1, pp. 11–17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. C. Mathieu, M. Waer, K. Casteels, J. Laureys, and R. Bouillon, “Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060,” Endocrinology, vol. 136, no. 3, pp. 866–872, 1995. View at Google Scholar · View at Scopus
  55. S. Gregori, N. Giarratana, S. Smiroldo, M. Uskokovic, and L. Adorini, “A 1alpha,25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice,” Diabetes, vol. 51, no. 5, pp. 1367–1374, 2002. View at Publisher · View at Google Scholar · View at Scopus
  56. C. S. Zipitis and A. K. Akobeng, “Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis,” Archives of Disease in Childhood, vol. 93, no. 6, pp. 512–517, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. C. Albayrak, D. Albayrak, A. A. Kilinç, and C. Kara, “Myelofibrosis associated with rickets in a child with down syndrome,” Pediatric Blood & Cancer, vol. 58, no. 4, pp. 647–648, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Stagi, L. Cavalli, C. Iurato, S. Seminara, M. L. Brandi, and M. D. Martino, “Bone metabolism in children and adolescents: main characteristics of the determinants of peak bone mass,” Clinical Cases in Mineral and Bone Metabolism, vol. 10, no. 3, pp. 172–179, 2013. View at Google Scholar · View at Scopus
  59. T. W. Fowler, K. D. McKelvey, N. S. Akel et al., “Low bone turnover and low BMD in down syndrome: effect of intermittent PTH treatment,” PLoS ONE, vol. 7, no. 8, Article ID e42967, 2012. View at Publisher · View at Google Scholar · View at Scopus
  60. K. D. McKelvey, T. W. Fowler, N. S. Akel et al., “Low bone turnover and low bone density in a cohort of adults with Down syndrome,” Osteoporosis International, vol. 24, no. 4, pp. 1333–1338, 2013. View at Publisher · View at Google Scholar · View at Scopus