Clinical Study
Determinants of Vitamin D Levels in Children and Adolescents with Down Syndrome
Table 1
Biochemical and demographic parameters in Down syndrome and healthy controls at baseline and at the end of the intervention.
| | Baseline | End of the study | | Down | Controls | Down | Controls |
| 25(OH)D, ng/mL | 14.34 ± 8.31 | 27.04 ± 7.47 | 20.15 ± 10.88 | 28.27 ± 7.96 | Children | 14.26 ± 8.71 | 27.89 ± 6.00 | 19.00 ± 11.49 | 28.99 ± 6.22 | Adolescents | 14.45 ± 8.15 | 20.34 ± 8.45 | 22.09 ± 9.72 | 23.55 ± 9.03 | Total calcium, mmol/L | 2.42 ± 0.14 | 2.51 ± 0.10 | 2.44 ± 0.31 | 2.54 ± 0.19 | Phosphorous, mmol/L | 1.32 ± 0.24 | 1.30 ± 0.32 | 1.31 ± 0.33 | 1.32 ± 0.39 | Bone specific alkaline phosphate, U/L | 58.3 ± 20.1 | 100.1 ± 31.2 | 78.1 ± 25.6 | 100.9 ± 35.7 | Parathyroid hormone, pmol/L | 54.76 ± 32.15 | 26.13 ± 10.76 | 43.57 ± 14.05 | 26.89 ± 13.56 | Cholecalciferol dietary intake, IU/day | 130 ± 38 | 143 ± 46 | 164 ± 46 | 179 ± 63 | Calcium intake, mg/day | 796 ± 283 | 821 ± 256 | 846 ± 256 | 889 ± 221 | Children | 810 ± 270 | 835 ± 285 | 864 ± 231 | 898 ± 200 | Adolescents | 755 ± 290 | 790 ± 235 | 812 ± 277 | 856 ± 231 | Systolic BP, mmHg | 115.9 ± 8.7 | 111.3 ± 8.4 | 113.1 ± 7.7 | 111.6 ± 7.5 | Diastolic BP, mmHg | 68.2 ± 8.9 | 65.7 ± 8.3 | 66.7 ± 7.9 | 65.1 ± 8.0 | Total cholesterol, mmol/L | 4.05 ± 0.57 | 3.43 ± 0.61 | 3.73 ± 0.58 | 3.27 ± 0.52 | LDL cholesterol, mmol/L | 3.00 ± 0.50 | 2.82 ± 0.48 | 2.85 ± 0.56 | 2.78 ± 0.60 | Triglycerides, mmol/L | 1.68 ± 0.48 | 1.53 ± 0.41 | 1.51 ± 0.39 | 1.60 ± 0.37 |
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Down syndrome versus controls cross-sectional evaluation: < 0.005; < 0.0005. Controls (children) versus controls (adolescents) cross-sectional evaluation: . Down syndrome versus Down syndrome longitudinal evaluation: ; . #Down syndrome versus controls longitudinal evaluation: ; . Controls versus controls longitudinal evaluation: ; . !Controls (children) versus controls (adolescents) longitudinal evaluation: < 0.0005.
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