Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2015, Article ID 903186, 9 pages
http://dx.doi.org/10.1155/2015/903186
Research Article

Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase

Department of Neurology, The Affiliated Fourth Centre Hospital of Tianjin Medical University, Tianjin 300140, China

Received 27 September 2014; Revised 14 February 2015; Accepted 17 February 2015

Academic Editor: Małgorzata Kotula-Balak

Copyright © 2015 Yinhua Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. A. Donnan, M. Fisher, M. Macleod, and S. M. Davis, “Stroke,” The Lancet, vol. 371, no. 9624, pp. 1612–1623, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. E. Cohen and R. R. Leker, “Intravenous thrombolytic therapy for acute ischemic stroke,” The New England Journal of Medicine, vol. 365, no. 10, pp. 964–965, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. K. A. Radermacher, K. Wingler, P. Kleikers et al., “The 1027th target candidate in stroke: will NADPH oxidase hold up?” Experimental & Translational Stroke Medicine, vol. 4, no. 1, article 11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. J.-M. Li, N. P. Gall, D. J. Grieve, M. Chen, and A. M. Shah, “Activation of NADPH oxidase during progression of cardiac hypertrophy to failure,” Hypertension, vol. 40, no. 4, pp. 477–484, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Chen, G. S. Kim, N. Okami, P. Narasimhan, and P. H. Chan, “NADPH oxidase is involved in post-ischemic brain inflammation,” Neurobiology of Disease, vol. 42, no. 3, pp. 341–348, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Du, L. M. Fan, A. Mai, and J.-M. Li, “Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice,” British Journal of Pharmacology, vol. 170, no. 5, pp. 1064–1077, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. C.-Y. Lu, Y.-C. Yang, C.-C. Li, K.-L. Liu, C.-K. Lii, and H.-W. Chen, “Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells,” Biochemical Pharmacology, vol. 91, no. 1, pp. 40–50, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Pandey and D. J. R. Fulton, “Molecular regulation of NADPH oxidase 5 via the MAPK pathway,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 300, no. 4, pp. H1336–H1344, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Kim, D. W. Kim, D. Y. Yoo et al., “Neuroprotective effects of PEP-1-Cu,Zn-SOD against ischemic neuronal damage in the rabbit spinal cord,” Neurochemical Research, vol. 37, no. 2, pp. 307–313, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Mizuno, T. Kume, C. Muto et al., “Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)—antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate,” Journal of Pharmacological Sciences, vol. 115, no. 3, pp. 320–328, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Sayin, P. Temiz, A. Var, and C. Temiz, “The dose-dependent neuroprotective effect of alpha-lipoic acid in experimental spinal cord injury,” Neurologia i Neurochirurgia Polska, vol. 47, no. 4, pp. 345–351, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Ahmadi, N. Mazooji, J. Roozbeh, Z. Mazloom, and J. Hasanzade, “Effect of alpha-lipoic acid and vitamin E supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients,” Iranian Journal of Kidney Diseases, vol. 7, no. 6, pp. 461–467, 2013. View at Google Scholar · View at Scopus
  13. Y. Yang, W. Wang, Y. Liu et al., “α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells,” Development, Growth & Differentiation, vol. 54, no. 5, pp. 557–565, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. B. J. Connell, M. Saleh, B. V. Khan, and T. M. Saleh, “Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia,” Brain Research, vol. 1375, pp. 128–136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. W. M. Clark, L. G. Rinker, N. S. Lessov, S. L. Lowery, and M. J. Cipolla, “Efficacy of antioxidant therapies in transient focal ischemia in mice,” Stroke, vol. 32, no. 4, pp. 1000–1004, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Diesel, S. Kulhanek-Heinze, M. Höltje et al., “α-Lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis,” Biochemistry, vol. 46, no. 8, pp. 2146–2155, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. S. Raza, M. M. Khan, A. Ahmad et al., “Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke,” Neuroscience, vol. 230, pp. 157–171, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Z. Longa, P. R. Weinstein, S. Carlson, and R. Cummins, “Reversible middle cerebral artery occlusion without craniectomy in rats,” Stroke, vol. 20, no. 1, pp. 84–91, 1989. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Belayev, O. F. Alonso, R. Busto, W. Zhao, and M. D. Ginsberg, “Middle cerebral artery occlusion in the rat by intraluminal suture: neurological and pathological evaluation of an improved model,” Stroke, vol. 27, no. 9, pp. 1616–1623, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. J.-M. Li, A. M. Mullen, S. Yun et al., “Essential role of the NADPH oxidase subunit p47phox in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-α,” Circulation Research, vol. 90, no. 2, pp. 143–150, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. M.-A. Barbacanne, J.-P. Souchard, B. Darblade et al., “Detection of superoxide anion released extracellularly by endothelial cells using cytochrome c reduction, ESR, fluorescence and lucigenin-enhanced chemiluminescence techniques,” Free Radical Biology & Medicine, vol. 29, no. 5, pp. 388–396, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Rodrigo, R. Fernández-Gajardo, R. Gutiérrez et al., “Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities,” CNS & Neurological Disorders—Drug Targets, vol. 12, no. 5, pp. 698–714, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Sinha, J. Das, P. B. Pal, and P. C. Sil, “Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis,” Archives of Toxicology, vol. 87, no. 7, pp. 1157–1180, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. E. Walder, S. P. Green, W. C. Darbonne et al., “Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase,” Stroke, vol. 28, no. 11, pp. 2252–2258, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Chen, Y. S. Song, and P. H. Chan, “Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion,” Journal of Cerebral Blood Flow & Metabolism, vol. 29, no. 7, pp. 1262–1272, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Konrad, “Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid—reduction or oxidation?” Antioxidants & Redox Signaling, vol. 7, no. 7-8, pp. 1032–1039, 2005. View at Publisher · View at Google Scholar · View at Scopus