Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women
Table 1
Clinical and biochemical characters of the study subject groups: overweight/obese (OW/OB), lean, lean with PCOS, and overweight/obese (OW/OB) PCOS subjects.
Variables
Non-PCOS ()
PCOS ()
value
Lean ()
OW/OB ()
Lean + PCOS ()
OW/OB + PCOS ()
Age (years)
21.00 (1.30)
21.50 (1.59)
21.10 (1.85)
21.25 (1.49)
0.997
BMI (kg/m2)
20.867 (2.41)
28.93 (3.74)
20.93 (3.03)
28.64 (2.89)
<0.0001
mFG score
14.00 (11.00–15.00)
11.50 (8.00–15.50)
13.0 (9.5–19.8)
15 (13.8–16.5)
<0.0001
Glucose (mg/dL)
89.00 (82.00–95.00)
92.00 (79.00–97.25)
85.5 (79.81–99.32)
95 (89.31–101.56)
0.689
Estradiol (pmol/L)
323.00 (145.00–522.00)
156.00 (124.00–223.50)
194 (139.80–294.80)
221 (80.00–442.00)
0.676
Progesterone (nmol/L)
0.60 (0.50–2.00)
1.40 (0.40–4.25)
0.6 (0.45–10.50)
0.9 (0.73–8.00)
0.946
Testosterone (nmol/L)
1.02 (0.52–1.66)
1.26 (0.53–1.98)
1.67 (0.91–2.77)
2.77 (2.10–4.05)
<0.0001
DHEAS (mol/L)
6.69 (5.35–8.77)
7.87 (6.55–8.55)
8.06 (5.18–10.16)
11.51 (10.23–14.71)
<0.0001
SHBG (nmol/L)
57.00 (45.50–72.50)
37.00 (33.00–65.00)
33 (28.5–50.5)
36 (18.75–60.75)
0.279
FAI
1.49 (0.72–3.33)
1.74 (1.13–3.71)
5.3 (2.4–10.9)
10.8 (3.8–14.6)
<0.0001
Free testosterone (nmol/L)
0.010 (0.005–0.021)
0.018 (0.008–0.028)
0.032 (0.015–0.057)
0.059 (0.027–0.079)
<0.0001
Prolactin (mIU/L)
306.00 (223.0–377.0)
300.50 (244.0–372.7)
368 (289–397.5)
375 (213.1–547.0)
0.419
Insulin (U/mL)>
11 (6.5–23.00)
11 (6.5–23.00)
10 (5.5–32.5)
28.5 (13.3–43.0)
0.327
TSH (mIU/L)
1.20 (0.95–2.40)
1.20 (0.95–2.40)
1.36 (1.07–2.44)
1.73 (1.08–3.39)
0.069
Free T4 (pmol/L)
14.20 (12.80–14.60)
14.20 (12.80–14.60)
15.1 (13.4–16.5)
14.2 (10.5–14.5)
0.560
HOMA (IR)
2.05 (1.26–5.30)
2.05 (1.26–5.30)
3.8 (2.91–7.62)
8.6 (2.24–13.95)
0.799
Data are presented by median and interquartile (IQ) values (25%–76%). Data were analyzed by nonparametric Wilcoxon/Kruskal-Wallis test for all group and pair-test with nonparametric comparisons for each pair using Wilcoxon method. OW/OB (overweight/obese); body mass index (BMI); mean modified Ferriman-Galleway (mFG); free androgen index (FAI); thyroxin (T4); dehydroepiandrosterone sulfate (DHEAS); thyroid-stimulating hormone (TSH); sex hormone binding globulin (SHBG). value for comparison of all groups. OW/OB PCOS is significantly different from lean PCOS with , OW/OB PCOS is significantly different from OW/OB Non-PCOS with , OW/OB Non-PCOS is significantly different from lean Non-PCOS with , and Lean Non-PCOS is significantly different from lean PCOS with . Two-tailed value less than 0.05 (<0.05) is significant.
