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International Journal of Endocrinology
Volume 2015, Article ID 950571, 9 pages
http://dx.doi.org/10.1155/2015/950571
Research Article

Sitagliptin: Is It Effective in Routine Clinical Practice?

1Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia
3Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 26 July 2014; Revised 8 September 2014; Accepted 8 September 2014

Academic Editor: Ilias Migdalis

Copyright © 2015 Rita Mohan Dallumal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. The present study was conducted to determine the glycaemic effects of sitagliptin in type 2 diabetes patients. Methods. Data was collected from patient medical records of a major teaching hospital in Malaysia, from 2009 to 2012. Glycated hemoglobin () values prior to and up to 12 months after the initiation of sitagliptin were analysed. The change in values was accounted for based on a generalized linear model generated using the Generalized Estimating Equations (GEE) method. Results and Discussion. Of the 457 patients, 53.6% were elderly and 81.4% were overweight. The mean (standard deviation) before initiation of sitagliptin was 8.5 (1.4)%. This dropped to 7.7 (1.4)%, 3 to 6 months after initiation of sitagliptin, with a mean difference of 0.8% (95% confidence interval (CI): 0.7–1.0; ). However, this value increased to 8.0 (1.7)% after 7 to 12 months on sitagliptin () with a mean difference from baseline of 0.6% (95% CI: 0.4–0.7; ). Conclusion. In routine clinical practice, sitagliptin produces a significant reduction in mean (0.8%) within the first 6 months of use which corresponds to efficacy data obtained in controlled clinical trials. However, this reduction was lesser, 7 to 12 month later.