Differences in miRNA and mRNA Profile of Papillary Thyroid Cancer Variants

Figure 3

Putative miRNA-gene regulations. Pairs hsa-miR-146b-5p with PHKB (a), hsa-miR-146b-5p with IRAK1, (b) and hsa-miR-874-3p with ITGB4 (c) were selected from best inverse Spearman’s correlations (below −0.65) within 321 cPTC samples and confirmed with miRanda, TargetScan, and TargetRank prediction algorithms. Pair hsa-miR-152-3p with TGFA (d) was selected from best inverse Spearman’s correlations (below −0.70) within 99 fvPTC samples and confirmed with miRanda, TargetScan, and TargetRank algorithms. Gene expression values were plotted on -axis whereas miRNA expression values on -axis. Both cPTC (filled dots) and fvPTC (empty dots) samples are depicted. Lines on graphs represent regression lines (gene expression values ~ miRNA expression values) for cPTC samples ((a), (b), (c)) and regression line for fvPTC samples (d). Approximated correlation coefficients () are calculated for both cPTC and fvPTC samples and presented in the above graphs.

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