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International Journal of Endocrinology
Volume 2016, Article ID 1674950, 5 pages
Clinical Study

Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome

1Department of Obstetrics & Gynecology, Santo Spirito Hospital, 00193 Rome, Italy
2Altamedica IVF Unit, 00198 Rome, Italy
3Reproductive Medicine Unit, University Hospital, 98122 Messina, Italy

Received 1 July 2016; Accepted 7 September 2016

Academic Editor: John E. Nestler

Copyright © 2016 Mario Montanino Oliva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility.