Myo-Ins significantly reduced E2 at hCG administration, total r-FSH units, number of stimulation days, and number of VG-DEG, with a trend for increased percentage of oocytes in MII. Number of oocytes retrieved did not differ in the 2 groups.
Myo-Ins has a positive effect on mature oocytes development and reduction of E2 and total r-FSH. Number of follicles with a diameter >15 mm visible at ultrasound scan during stimulation and the number of oocytes retrieved at the pick-up resulted significantly higher in the Myo-Ins-treated group. The number of immature oocytes was significantly reduced, and there was an increasing trend of the rate of oocytes in MII.
Both Myo-Ins and metformin can be considered as first-line treatment for restoring normal menstrual cycles in most patients with PCOS; however Myo-Ins treatment seems to be more effective than metformin.
Myo-Ins significantly increased number of MII and decreased number of immature oocytes compared to D-chiro-Ins. Furthermore, it increased the mean number of top quality embryos and the total number of pregnancies compared to D-chiro-Ins. Number of oocytes retrieved did not differ in the two treatments groups.
The combined treatment with Myo-Ins + D-chiro-Ins, rather than D-chiro-Ins alone, was able to improve oocyte quality and high-quality embryos in PCOS women undergoing ART regardless of the age.
2,185.09 ± 409.08 versus 2,519.85 ± 788.49
1,906.96 ± 770.59 versus 2,170.58 ± 694.44
6.91 ± 2.26 versus 8.35 ± 5.19
8.35 ± 3.21 versus 10.75 ± 5.23
0.90 ± 0.80 versus 0.68 ± 0.80
Myo-Ins, myo-inositol; D-chiro-Ins, D-chiro-inositol; FA, folic acid; PCOS, polycystic ovary syndrome; E2, oestradiol; r-FSH, recombinant follicle stimulating hormone; MII, mature oocytes; VG-DEG, immature oocytes and degenerated oocytes; hCG, Human Chorionic Gonadotropin; ART, assisted reproductive technology. Values are mean ± SD. Values are shown as median. A brief description is inserted in the table when numerical data are not available. value: ≤0.05; ≤0.01; ≤0.001: comparison posttreatment experimental group versus control.
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